DegronMD

Uniprot ID: Q8NG31

Source protein: Kinetochore scaffold 1

Source gene: KNL1

Class: DEG_APCC_KENBOX_2

Location: 261:265

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9962

ASA_SCORE: 102.36

COIL: 0.7168

CONS_SCORE: 0.6238

DSS_SCORE: 0.4358

HELIX: 0.1166

FCONS_SCORE: 1.7206

RIG_SCORE: 0.7663

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C253Y	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DKENF	DEG_APCC_KENBOX_2	0.1111
p.C253Y	NCI-H1155	lung	COSMIC	DKENF	DEG_APCC_KENBOX_2	0.1111
p.K262N	SIDM01019	Acute Myeloid Leukemia	GDSC	DKENF	DEG_APCC_KENBOX_2	0.6918
p.K262N	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	DKENF	DEG_APCC_KENBOX_2	0.6918
p.P257L	SIDM00494	Non-Small Cell Lung Carcinoma	GDSC	DKENF	DEG_APCC_KENBOX_2	0.2222
p.P257L	ABC-1	lung	COSMIC	DKENF	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NG31	Kinetochore scaffold 1	DEG_APCC_KENBOX_2	261:265	DKENF	APC,CDC20,FZR1	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons