DegronMD

Uniprot ID: Q8NG31

Source protein: Kinetochore scaffold 1

Source gene: KNL1

Class: LIG_APCC_ABBA_1

Location: 1742:1747

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9774

ASA_SCORE: 74.8167

COIL: 0.7735

CONS_SCORE: 0.4705

DSS_SCORE: 0.4847

HELIX: 0.2003

FCONS_SCORE: 1.1432

RIG_SCORE: 0.7694

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1743L	SIDM00282	Colorectal Carcinoma	GDSC	LPVYPD	LIG_APCC_ABBA_1	0.6471
p.P1743L	CW-2	large_intestine	COSMIC	LPVYPD	LIG_APCC_ABBA_1	0.6471
p.E1745A	RKO	large_intestine	COSMIC	LPVYPD	LIG_APCC_ABBA_1	0.7701
p.R1741T	DU-145	prostate	COSMIC	LPVYPD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NG31	Kinetochore scaffold 1	LIG_APCC_ABBA_1	1742:1747	LPVYPD	APC,CDC20,FZR1	0.9774	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons