DegronMD

Uniprot ID: Q8NG31

Source protein: Kinetochore scaffold 1

Source gene: KNL1

Class: LIG_APCC_ABBA_1

Location: 212:217

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9447

ASA_SCORE: 104.4

COIL: 0.7712

CONS_SCORE: 0.4355

DSS_SCORE: 0.329

HELIX: 0.2145

FCONS_SCORE: 1.0079

RIG_SCORE: 0.7861

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E217K	SIDM01199	Hepatocellular Carcinoma	GDSC	LKLHTE	LIG_APCC_ABBA_1	0.7022
p.E217K	SIDM00383	Gastric Carcinoma	GDSC	LKLHTE	LIG_APCC_ABBA_1	0.7022
p.E217K	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	LKLHTE	LIG_APCC_ABBA_1	0.7022
p.E217K	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	LKLHTE	LIG_APCC_ABBA_1	0.7022
p.E217K	SIDM01450	Gastric Carcinoma	GDSC	LKLHTE	LIG_APCC_ABBA_1	0.7022
p.E217K	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	LKLHTE	LIG_APCC_ABBA_1	0.7022
p.C227Y	NCI-H1155	lung	COSMIC	LKLHTE	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NG31	Kinetochore scaffold 1	LIG_APCC_ABBA_1	212:217	LKLHTE	APC,CDC20,FZR1	0.9447	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons