DegronMD

Uniprot ID: Q8NG31

Source protein: Kinetochore scaffold 1

Source gene: KNL1

Class: DEG_SPOP_SBC_1

Location: 621:625

E3 ligase: SPOP

DEGRON score: 0.798

ASA_SCORE: 95.12

COIL: 0.8618

CONS_SCORE: 0.3155

DSS_SCORE: 0.6113

HELIX: 0.1006

FCONS_SCORE: 0.9203

RIG_SCORE: 0.5816

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q611R	SIDM00553	Acute Myeloid Leukemia	GDSC	PESTS	DEG_SPOP_SBC_1	0.0556
p.Q611R	SIDM00333	Endometrial Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	0.0556
p.Q611R	SIDM01372	Pancreatic Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	0.0556
p.N618S	SIDM00050	Chondrosarcoma	GDSC	PESTS	DEG_SPOP_SBC_1	0.25
p.N618S	SIDM00105	Ovarian Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	0.25
p.N618S	SIDM00093	Ovarian Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	0.25
p.N618S	OVCAR-3	ovary	COSMIC	PESTS	DEG_SPOP_SBC_1	0.25
p.N618S	CHSA0108	bone	COSMIC	PESTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00221	NF-kappa-B inhibitor epsilon	DEG_SPOP_SBC_1	169:173	PESTS	SPOP	0.9067	More...
P53804	E3 ubiquitin-protein ligase TTC3	DEG_SPOP_SBC_1	1449:1453	PESTS	SPOP	0.7321	More...
P58753	Toll/interleukin-1 receptor domain-containing adapter protein	DEG_SPOP_SBC_1	40:44	PESTS	SPOP	0.9402	More...
P63252	Inward rectifier potassium channel 2	DEG_SPOP_SBC_1	395:399	PESTS	SPOP	0.5469	More...
Q13635	Protein patched homolog 1	DEG_SPOP_SBC_1	702:706	PESTS	SPOP	0.5289	More...
Q8NG31	Kinetochore scaffold 1	DEG_SPOP_SBC_1	621:625	PESTS	SPOP	0.798	More...
Q9BT25	HAUS augmin-like complex subunit 8	DEG_SPOP_SBC_1	127:131	PESTS	SPOP	0.9807	More...
Q9Y4A8	Nuclear factor erythroid 2-related factor 3	DEG_SPOP_SBC_1	507:511	PESTS	SPOP	0.8238	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	465:469	PESTS	SPOP	0.9571	More...
C9JH25	Proline-rich transmembrane protein 4	DEG_SPOP_SBC_1	129:133	PESTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons