DegronMD

Uniprot ID: O00221

Source protein: NF-kappa-B inhibitor epsilon

Source gene: NFKBIE

Class: DEG_SPOP_SBC_1

Location: 169:173

E3 ligase: SPOP

DEGRON score: 0.9067

ASA_SCORE: 88.98

COIL: 0.9136

CONS_SCORE: 0.4186

DSS_SCORE: 0.7509

HELIX: 0.0652

FCONS_SCORE: 0.96

RIG_SCORE: 0.5379

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T172A	TCGA-D8-A1XK	BRCA	TCGA	PESTS	DEG_SPOP_SBC_1	0.7139
p.T172A	DO4749	BRCA	ICGC	PESTS	DEG_SPOP_SBC_1	0.7139
p.P175L	DO229003	COCA	ICGC	PESTS	DEG_SPOP_SBC_1	0.2778
p.P175L	DO229005	COCA	ICGC	PESTS	DEG_SPOP_SBC_1	0.2778
p.P175L	DO223154	ESCA	ICGC	PESTS	DEG_SPOP_SBC_1	0.2778
p.P175L	DO229346	LAML	ICGC	PESTS	DEG_SPOP_SBC_1	0.2778
p.P175L	DO229480	LAML	ICGC	PESTS	DEG_SPOP_SBC_1	0.2778
p.P175L	DO230934	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	0.2778
p.P175L	DO230990	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	0.2778
p.P175L	DO231102	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	0.2778
p.P175L	DO231114	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	0.2778
p.L162M	DO229221	THCA	ICGC	PESTS	DEG_SPOP_SBC_1	0.1389
p.S171P	ACH-000541	Myeloma	CCLE	PESTS	DEG_SPOP_SBC_1	0.6752
p.S171P	ACH-000672	Lung Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	0.6752
p.R163C	ACH-000990	Endometrial/Uterine Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	0.1667
p.R172Q	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	PESTS	DEG_SPOP_SBC_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00221	NF-kappa-B inhibitor epsilon	DEG_SPOP_SBC_1	169:173	PESTS	SPOP	0.9067	More...
P53804	E3 ubiquitin-protein ligase TTC3	DEG_SPOP_SBC_1	1449:1453	PESTS	SPOP	0.7321	More...
P58753	Toll/interleukin-1 receptor domain-containing adapter protein	DEG_SPOP_SBC_1	40:44	PESTS	SPOP	0.9402	More...
P63252	Inward rectifier potassium channel 2	DEG_SPOP_SBC_1	395:399	PESTS	SPOP	0.5469	More...
Q13635	Protein patched homolog 1	DEG_SPOP_SBC_1	702:706	PESTS	SPOP	0.5289	More...
Q8NG31	Kinetochore scaffold 1	DEG_SPOP_SBC_1	621:625	PESTS	SPOP	0.798	More...
Q9BT25	HAUS augmin-like complex subunit 8	DEG_SPOP_SBC_1	127:131	PESTS	SPOP	0.9807	More...
Q9Y4A8	Nuclear factor erythroid 2-related factor 3	DEG_SPOP_SBC_1	507:511	PESTS	SPOP	0.8238	More...
Q8N3X1	Formin-binding protein 4	DEG_SPOP_SBC_1	465:469	PESTS	SPOP	0.9571	More...
C9JH25	Proline-rich transmembrane protein 4	DEG_SPOP_SBC_1	129:133	PESTS	SPOP	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons