DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PESTS
Uniprot ID:
Q8N3X1
Source protein:
Formin-binding protein 4
Source gene:
FNBP4
Class:
DEG_SPOP_SBC_1
Location:
465:469
E3 ligase:
SPOP
DEGRON score:
0.9571
ASA_SCORE:
91
COIL:
0.8836
CONS_SCORE:
0.5253
DSS_SCORE:
0.6443
HELIX:
0.084
FCONS_SCORE:
1.1585
RIG_SCORE:
0.5872
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S472C
TCGA-3C-AALI
BRCA
TCGA
PESTS
DEG_SPOP_SBC_1
0.25
p.S472C
DO219589
BRCA
ICGC
PESTS
DEG_SPOP_SBC_1
0.25
p.D478N
TCGA-55-6968
LUAD
TCGA
PESTS
DEG_SPOP_SBC_1
0.0833
p.D478N
DO23759
LUAD
ICGC
PESTS
DEG_SPOP_SBC_1
0.0833
p.P465A
TCGA-A2-A0CX
BRCA
TCGA
PESTS
DEG_SPOP_SBC_1
0.6392
p.P465A
DO2755
BRCA
ICGC
PESTS
DEG_SPOP_SBC_1
0.6392
p.S467C
TCGA-Q1-A73O
CESC
TCGA
PESTS
DEG_SPOP_SBC_1
0.7541
p.S467C
DO51612
CESC
ICGC
PESTS
DEG_SPOP_SBC_1
0.7541
p.S472F
TCGA-XF-AAN0
BLCA
TCGA
PESTS
DEG_SPOP_SBC_1
0.25
p.S472F
DO51941
BLCA
ICGC
PESTS
DEG_SPOP_SBC_1
0.25
p.S472A
DO228672
LICA
ICGC
PESTS
DEG_SPOP_SBC_1
0.25
p.T463I
SIDM01228
Melanoma
GDSC
PESTS
DEG_SPOP_SBC_1
0.2778
p.T463I
ACH-000931
Skin Cancer
CCLE
PESTS
DEG_SPOP_SBC_1
0.2778
p.T463I
ACH-001024
Skin Cancer
CCLE
PESTS
DEG_SPOP_SBC_1
0.2778
p.T463I
CHL-1
skin
COSMIC
PESTS
DEG_SPOP_SBC_1
0.2778
Drug responses associated with FNBP4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PESTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O00221
NF-kappa-B inhibitor epsilon
DEG_SPOP_SBC_1
169:173
PESTS
SPOP
0.9067
More...
P53804
E3 ubiquitin-protein ligase TTC3
DEG_SPOP_SBC_1
1449:1453
PESTS
SPOP
0.7321
More...
P58753
Toll/interleukin-1 receptor domain-containing adapter protein
DEG_SPOP_SBC_1
40:44
PESTS
SPOP
0.9402
More...
P63252
Inward rectifier potassium channel 2
DEG_SPOP_SBC_1
395:399
PESTS
SPOP
0.5469
More...
Q13635
Protein patched homolog 1
DEG_SPOP_SBC_1
702:706
PESTS
SPOP
0.5289
More...
Q8NG31
Kinetochore scaffold 1
DEG_SPOP_SBC_1
621:625
PESTS
SPOP
0.798
More...
Q9BT25
HAUS augmin-like complex subunit 8
DEG_SPOP_SBC_1
127:131
PESTS
SPOP
0.9807
More...
Q9Y4A8
Nuclear factor erythroid 2-related factor 3
DEG_SPOP_SBC_1
507:511
PESTS
SPOP
0.8238
More...
Q8N3X1
Formin-binding protein 4
DEG_SPOP_SBC_1
465:469
PESTS
SPOP
0.9571
More...
C9JH25
Proline-rich transmembrane protein 4
DEG_SPOP_SBC_1
129:133
PESTS
SPOP
0.9849
More...