DegronMD - C9JH25(PRRT4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P129L	TCGA-2W-A8YY	CESC	TCGA	PESTS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7582
p.P129L	DO223732	CESC	ICGC	PESTS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7582
p.S125P	TCGA-AP-A1DK	UCEC	TCGA	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2222
p.S125P	DO42033	UCEC	ICGC	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2222
p.R123W	TCGA-AZ-6601	COAD	TCGA	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1667
p.R123W	DO8119	COAD	ICGC	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1667
p.R123Q	TCGA-BG-A18B	UCEC	TCGA	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1667
p.R123Q	TCGA-KH-A6WC	ESCA	TCGA	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1667
p.R123Q	DO41452	UCEC	ICGC	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1667
p.R123Q	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1667
p.R123Q	ACH-000747	Lung Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1667
p.D823N	DO639	BLCA	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	826:834	Mutation rewiring degron network	0.25
p.R135C	DO230336	COCA	ICGC	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2778
p.R134Q	DO229013	COCA	ICGC	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.R134Q	DO229016	COCA	ICGC	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.R134Q	DO230659	LAML	ICGC	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.R134Q	DO231106	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.R134Q	DO231141	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.P826L	DO229013	COCA	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	826:834	Mutation altering degron motif	0.6471
p.P826L	DO229016	COCA	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	826:834	Mutation altering degron motif	0.6471
p.P826L	DO229353	LAML	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	826:834	Mutation altering degron motif	0.6471
p.P826L	DO229505	LAML	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	826:834	Mutation altering degron motif	0.6471
p.P826L	DO230937	LUSC	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	826:834	Mutation altering degron motif	0.6471
p.P826L	DO230998	LUSC	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	826:834	Mutation altering degron motif	0.6471
p.R827C	DO234347	ESAD	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	826:834	Mutation altering degron motif	0.8301
p.R827C	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PRCPLVCVL	DEG_APCC_DBOX_1	826:834	Mutation altering degron motif	0.8301
p.R827H	DO233270	GACA	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	826:834	Mutation altering degron motif	0.8244
p.P839L	DO231569	LINC	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	826:834	Mutation rewiring degron network	0.1944
p.R135H	SIDM01307	Colorectal Carcinoma	GDSC	PESTS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRRT4

UniProt ID: C9JH25

Entrez ID: 401399

Protein name: Proline-rich transmembrane protein 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRRT4 in