DegronMD

Uniprot ID: C9JH25

Source protein: Proline-rich transmembrane protein 4

Source gene: PRRT4

Class: DEG_APCC_DBOX_1

Location: 826:834

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9066

ASA_SCORE: 85.3778

COIL: 0.9148

CONS_SCORE: 0.9914

DSS_SCORE: 0.3605

HELIX: 0.0309

FCONS_SCORE: 1.0342

RIG_SCORE: 0.7457

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D823N	DO639	BLCA	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	0.25
p.P826L	DO229013	COCA	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	0.6471
p.P826L	DO229016	COCA	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	0.6471
p.P826L	DO229353	LAML	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	0.6471
p.P826L	DO229505	LAML	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	0.6471
p.P826L	DO230937	LUSC	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	0.6471
p.P826L	DO230998	LUSC	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	0.6471
p.R827C	DO234347	ESAD	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	0.8301
p.R827C	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PRCPLVCVL	DEG_APCC_DBOX_1	0.8301
p.R827H	DO233270	GACA	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	0.8244
p.P839L	DO231569	LINC	ICGC	PRCPLVCVL	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
C9JH25	Proline-rich transmembrane protein 4	DEG_APCC_DBOX_1	826:834	PRCPLVCVL	APC,CDC20,FZR1	0.9066	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons