DegronMD - P53804(TTC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1342F	TCGA-49-AARO	LUAD	TCGA	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1667
p.L1342F	TCGA-AN-A03X	BRCA	TCGA	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1667
p.L1342F	DO2885	BRCA	ICGC	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1667
p.L1342F	DO218924	LUAD	ICGC	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1667
p.K1026N	TCGA-64-1681	LUAD	TCGA	PFSST	DEG_SPOP_SBC_1	1013:1017	Mutation substituting flanking lysine	0.1944
p.K1026N	DO23899	LUAD	ICGC	PFSST	DEG_SPOP_SBC_1	1013:1017	Mutation substituting flanking lysine	0.1944
p.H1460Y	TCGA-CF-A47Y	BLCA	TCGA	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.1389
p.H1460Y	DO44050	BLCA	ICGC	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.1389
p.V1338M	TCGA-CG-5721	STAD	TCGA	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.0556
p.V1338M	DO38192	STAD	ICGC	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.0556
p.N1457S	TCGA-CG-5721	STAD	TCGA	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.2222
p.N1457S	DO38192	STAD	ICGC	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.2222
p.Q1462R	TCGA-DD-A1EE	LIHC	TCGA	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.0833
p.Q1462R	TCGA-G3-A25S	LIHC	TCGA	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.0833
p.Q1462R	DO23018	LIHC	ICGC	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.0833
p.Q1462R	DO22857	LIHC	ICGC	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.0833
p.Q1462H	TCGA-DK-AA74	BLCA	TCGA	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.0833
p.Q1462H	DO219011	BLCA	ICGC	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.0833
p.G1439R	TCGA-FW-A3R5	SKCM	TCGA	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.0556
p.G1439R	DO37406	SKCM	ICGC	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.0556
p.Q1360P	TCGA-NJ-A4YF	LUAD	TCGA	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1667
p.Q1360P	DO218940	LUAD	ICGC	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1667
p.G1341C	DO228903	LICA	ICGC	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1389
p.A1012S	DO228974	LICA	ICGC	PFSST	DEG_SPOP_SBC_1	1013:1017	Mutation rewiring degron network	0.3056
p.G1341V	DO228976	LICA	ICGC	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1389
p.G1341V	DO229041	LICA	ICGC	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1389
p.V1003L	DO228976	LICA	ICGC	PFSST	DEG_SPOP_SBC_1	1013:1017	Mutation rewiring degron network	0.0556
p.K1018N	DO228985	LICA	ICGC	PFSST	DEG_SPOP_SBC_1	1013:1017	Mutation blocking ubiquitination signal	0.75
p.A1353S	DO229037	LICA	ICGC	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation altering degron motif	0.6477
p.G1010C	DO23372	LINC	ICGC	PFSST	DEG_SPOP_SBC_1	1013:1017	Mutation rewiring degron network	0.25
p.K1020R	DO23320	LINC	ICGC	PFSST	DEG_SPOP_SBC_1	1013:1017	Mutation substituting flanking lysine	0.3611
p.S1451C	DO23516	LIRI	ICGC	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation altering degron motif	0.7541
p.H1460Q	DO230929	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.1389
p.H1460Q	DO224572	LUSC	ICGC	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.1389
p.N1442K	DO229253	THCA	ICGC	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.1389
p.S1015T	SIDM02075	Colorectal Carcinoma	GDSC	PFSST	DEG_SPOP_SBC_1	1013:1017	Mutation altering degron motif	0.6005
p.A1353T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation altering degron motif	0.6028
p.A1353T	ACH-002256	Leukemia	CCLE	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation altering degron motif	0.6028
p.A1353T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation altering degron motif	0.6028
p.Q1360H	SIDM00293	Small Cell Lung Carcinoma	GDSC	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1667
p.Q1360H	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1667
p.Q1360H	ACH-000823	Esophageal Cancer	CCLE	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1667
p.Q1360H	ACH-001184	Sarcoma	CCLE	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1667
p.Q1360H	ACH-001515	Cervical Cancer	CCLE	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1667
p.Q1360H	ACH-002052	Lung Cancer	CCLE	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1667
p.Q1360H	LU-139	lung	COSMIC	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1667
p.Q1360H	KYSE-140	oesophagus	COSMIC	IYTPLAS	DEG_SCF_FBW7_1	1348:1354	Mutation rewiring degron network	0.1667
p.V1461M	SIDM00995	Other Solid Cancers	GDSC	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.1111
p.V1461M	ACH-001328	Skin Cancer	CCLE	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.1111
p.V1461M	A431	skin	COSMIC	PESTS	DEG_SPOP_SBC_1	1449:1453	Mutation rewiring degron network	0.1111

Kaplan plot for TTC3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTC3

UniProt ID: P53804

Entrez ID: 7267

Protein name: E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TTC3 in