DegronMD

Uniprot ID: P53804

Source protein: E3 ubiquitin-protein ligase TTC3

Source gene: TTC3

Class: DEG_SCF_FBW7_1

Location: 1348:1354

E3 ligase: FBXW7

DEGRON score: 0.9765

ASA_SCORE: 75.9571

COIL: 0.7551

CONS_SCORE: 0.5094

DSS_SCORE: 0.2105

HELIX: 0.171

FCONS_SCORE: 1.23

RIG_SCORE: 0.8117

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1342F	TCGA-49-AARO	LUAD	TCGA	IYTPLAS	DEG_SCF_FBW7_1	0.1667
p.L1342F	TCGA-AN-A03X	BRCA	TCGA	IYTPLAS	DEG_SCF_FBW7_1	0.1667
p.L1342F	DO2885	BRCA	ICGC	IYTPLAS	DEG_SCF_FBW7_1	0.1667
p.L1342F	DO218924	LUAD	ICGC	IYTPLAS	DEG_SCF_FBW7_1	0.1667
p.V1338M	TCGA-CG-5721	STAD	TCGA	IYTPLAS	DEG_SCF_FBW7_1	0.0556
p.V1338M	DO38192	STAD	ICGC	IYTPLAS	DEG_SCF_FBW7_1	0.0556
p.Q1360P	TCGA-NJ-A4YF	LUAD	TCGA	IYTPLAS	DEG_SCF_FBW7_1	0.1667
p.Q1360P	DO218940	LUAD	ICGC	IYTPLAS	DEG_SCF_FBW7_1	0.1667
p.G1341C	DO228903	LICA	ICGC	IYTPLAS	DEG_SCF_FBW7_1	0.1389
p.G1341V	DO228976	LICA	ICGC	IYTPLAS	DEG_SCF_FBW7_1	0.1389
p.G1341V	DO229041	LICA	ICGC	IYTPLAS	DEG_SCF_FBW7_1	0.1389
p.A1353S	DO229037	LICA	ICGC	IYTPLAS	DEG_SCF_FBW7_1	0.6477
p.A1353T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IYTPLAS	DEG_SCF_FBW7_1	0.6028
p.A1353T	ACH-002256	Leukemia	CCLE	IYTPLAS	DEG_SCF_FBW7_1	0.6028
p.A1353T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	IYTPLAS	DEG_SCF_FBW7_1	0.6028
p.Q1360H	SIDM00293	Small Cell Lung Carcinoma	GDSC	IYTPLAS	DEG_SCF_FBW7_1	0.1667
p.Q1360H	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	IYTPLAS	DEG_SCF_FBW7_1	0.1667
p.Q1360H	ACH-000823	Esophageal Cancer	CCLE	IYTPLAS	DEG_SCF_FBW7_1	0.1667
p.Q1360H	ACH-001184	Sarcoma	CCLE	IYTPLAS	DEG_SCF_FBW7_1	0.1667
p.Q1360H	ACH-001515	Cervical Cancer	CCLE	IYTPLAS	DEG_SCF_FBW7_1	0.1667
p.Q1360H	ACH-002052	Lung Cancer	CCLE	IYTPLAS	DEG_SCF_FBW7_1	0.1667
p.Q1360H	LU-139	lung	COSMIC	IYTPLAS	DEG_SCF_FBW7_1	0.1667
p.Q1360H	KYSE-140	oesophagus	COSMIC	IYTPLAS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53804	E3 ubiquitin-protein ligase TTC3	DEG_SCF_FBW7_1	1348:1354	IYTPLAS	FBXW7	0.9765	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons