DegronMD

Uniprot ID: P53804

Source protein: E3 ubiquitin-protein ligase TTC3

Source gene: TTC3

Class: DEG_SPOP_SBC_1

Location: 1013:1017

E3 ligase: SPOP

DEGRON score: 0.9797

ASA_SCORE: 63.8

COIL: 0.7664

CONS_SCORE: 0.3834

DSS_SCORE: 0.5772

HELIX: 0.128

FCONS_SCORE: 0.8038

RIG_SCORE: 0.6801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1026N	TCGA-64-1681	LUAD	TCGA	PFSST	DEG_SPOP_SBC_1	0.1944
p.K1026N	DO23899	LUAD	ICGC	PFSST	DEG_SPOP_SBC_1	0.1944
p.A1012S	DO228974	LICA	ICGC	PFSST	DEG_SPOP_SBC_1	0.3056
p.V1003L	DO228976	LICA	ICGC	PFSST	DEG_SPOP_SBC_1	0.0556
p.K1018N	DO228985	LICA	ICGC	PFSST	DEG_SPOP_SBC_1	0.75
p.G1010C	DO23372	LINC	ICGC	PFSST	DEG_SPOP_SBC_1	0.25
p.K1020R	DO23320	LINC	ICGC	PFSST	DEG_SPOP_SBC_1	0.3611
p.S1015T	SIDM02075	Colorectal Carcinoma	GDSC	PFSST	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RUB1	Meiosis-specific coiled-coil domain-containing protein MEIOC	DEG_SPOP_SBC_1	81:85	PFSST	SPOP	0.9486	More...
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	2349:2353	PFSST	SPOP	0.9988	More...
P53804	E3 ubiquitin-protein ligase TTC3	DEG_SPOP_SBC_1	1013:1017	PFSST	SPOP	0.9797	More...
Q9UNF0	Protein kinase C and casein kinase substrate in neurons protein 2	DEG_SPOP_SBC_1	406:410	PFSST	SPOP	0.9979	More...
O75808	Calpain-15	DEG_SPOP_SBC_1	234:238	PFSST	SPOP	0.9598	More...
Q53SZ7	Proline-rich protein 30	DEG_SPOP_SBC_1	50:54	PFSST	SPOP	0.8135	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons