DegronMD - Q53SZ7(PRR30)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P50R	SIDM00933	Breast Carcinoma	GDSC	PFSST	DEG_SPOP_SBC_1	50:54	Mutation altering degron motif	0.7512
p.P50R	SIDM00454	Rhabdomyosarcoma	GDSC	PFSST	DEG_SPOP_SBC_1	50:54	Mutation altering degron motif	0.7512
p.P50R	SIDM00087	Plasma Cell Myeloma	GDSC	PFSST	DEG_SPOP_SBC_1	50:54	Mutation altering degron motif	0.7512
p.P50R	SIDM00846	Cervical Carcinoma	GDSC	PFSST	DEG_SPOP_SBC_1	50:54	Mutation altering degron motif	0.7512
p.P50R	SIDM01099	Neuroblastoma	GDSC	PFSST	DEG_SPOP_SBC_1	50:54	Mutation altering degron motif	0.7512
p.P50R	SIDM00875	Breast Carcinoma	GDSC	PFSST	DEG_SPOP_SBC_1	50:54	Mutation altering degron motif	0.7512
p.P50R	SIDM01133	Other Solid Cancers	GDSC	PFSST	DEG_SPOP_SBC_1	50:54	Mutation altering degron motif	0.7512
p.P50R	SIDM00930	Osteosarcoma	GDSC	PFSST	DEG_SPOP_SBC_1	50:54	Mutation altering degron motif	0.7512
p.P45L	SIDM00719	Small Cell Lung Carcinoma	GDSC	PFSST	DEG_SPOP_SBC_1	50:54	Mutation rewiring degron network	0.1944
p.P45L	NCI-H345	lung	COSMIC	PFSST	DEG_SPOP_SBC_1	50:54	Mutation rewiring degron network	0.1944
p.P50S	SIDM00974	Melanoma	GDSC	PFSST	DEG_SPOP_SBC_1	50:54	Mutation altering degron motif	0.6752
p.P50S	WM35	skin	COSMIC	PFSST	DEG_SPOP_SBC_1	50:54	Mutation altering degron motif	0.6752
p.P126S	SIDM00177	Melanoma	GDSC	PPLTPSFS	DEG_SCF_FBW7_1	122:129	Mutation altering degron motif	0.6752
p.T353I	SIDM00526	Chronic Myelogenous Leukemia	GDSC	VPGTPSQT	DEG_SCF_FBW7_1	350:357	Mutation altering degron motif	0.7078
p.T353I	MEG-01	haematopoietic and lymphoid tissue	COSMIC	VPGTPSQT	DEG_SCF_FBW7_1	350:357	Mutation altering degron motif	0.7078
p.P122L	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PPLTPSFS	DEG_SCF_FBW7_1	122:129	Mutation altering degron motif	0.6471
p.P122L	KYSE-450	oesophagus	COSMIC	PPLTPSFS	DEG_SCF_FBW7_1	122:129	Mutation altering degron motif	0.6471
p.P122T	SIDM00721	Small Cell Lung Carcinoma	GDSC	PPLTPSFS	DEG_SCF_FBW7_1	122:129	Mutation altering degron motif	0.7031
p.P122T	NCI-H250	lung	COSMIC	PPLTPSFS	DEG_SCF_FBW7_1	122:129	Mutation altering degron motif	0.7031
p.I124N	NB-4	haematopoietic and lymphoid tissue	COSMIC	PPLTPSFS	DEG_SCF_FBW7_1	122:129	Mutation altering degron motif	0.728
p.L138I	NCI-H630	large intestine	COSMIC	PPLTPSFS	DEG_SCF_FBW7_1	122:129	Mutation rewiring degron network	0.0833
p.P341L	Sarc9371	bone	COSMIC	VPGTPSQT	DEG_SCF_FBW7_1	350:357	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRR30

UniProt ID: Q53SZ7

Entrez ID: 339779

Protein name: Proline-rich protein 30

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRR30 in