DegronMD

Uniprot ID: Q53SZ7

Source protein: Proline-rich protein 30

Source gene: PRR30

Class: DEG_SCF_FBW7_1

Location: 122:129

E3 ligase: FBXW7

DEGRON score: 0.9616

ASA_SCORE: 87.75

COIL: 0.9571

CONS_SCORE: 0.7243

DSS_SCORE: 0.5855

HELIX: 0.0231

FCONS_SCORE: 0.9664

RIG_SCORE: 0.5559

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P126S	SIDM00177	Melanoma	GDSC	PPLTPSFS	DEG_SCF_FBW7_1	0.6752
p.P122L	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PPLTPSFS	DEG_SCF_FBW7_1	0.6471
p.P122L	KYSE-450	oesophagus	COSMIC	PPLTPSFS	DEG_SCF_FBW7_1	0.6471
p.P122T	SIDM00721	Small Cell Lung Carcinoma	GDSC	PPLTPSFS	DEG_SCF_FBW7_1	0.7031
p.P122T	NCI-H250	lung	COSMIC	PPLTPSFS	DEG_SCF_FBW7_1	0.7031
p.I124N	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	PPLTPSFS	DEG_SCF_FBW7_1	0.728
p.L138I	NCI-H630	large_intestine	COSMIC	PPLTPSFS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53SZ7	Proline-rich protein 30	DEG_SCF_FBW7_1	122:129	PPLTPSFS	FBXW7	0.9616	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons