DegronMD

Uniprot ID: Q53SZ7

Source protein: Proline-rich protein 30

Source gene: PRR30

Class: DEG_SCF_FBW7_1

Location: 350:357

E3 ligase: FBXW7

DEGRON score: 0.9688

ASA_SCORE: 70.425

COIL: 0.8379

CONS_SCORE: 0.6343

DSS_SCORE: 0.7817

HELIX: 0.1156

FCONS_SCORE: 1.0305

RIG_SCORE: 0.5796

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T353I	SIDM00526	Chronic Myelogenous Leukemia	GDSC	VPGTPSQT	DEG_SCF_FBW7_1	0.7078
p.T353I	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	VPGTPSQT	DEG_SCF_FBW7_1	0.7078
p.P341L	Sarc9371	bone	COSMIC	VPGTPSQT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53SZ7	Proline-rich protein 30	DEG_SCF_FBW7_1	350:357	VPGTPSQT	FBXW7	0.9688	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons