DegronMD

Uniprot ID: O75808

Source protein: Calpain-15

Source gene: CAPN15

Class: DEG_SPOP_SBC_1

Location: 234:238

E3 ligase: SPOP

DEGRON score: 0.9598

ASA_SCORE: 74.82

COIL: 0.787

CONS_SCORE: 0.3147

DSS_SCORE: 0.7161

HELIX: 0.1812

FCONS_SCORE: 1.032

RIG_SCORE: 0.5855

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P230Q	TCGA-EM-A22L	THCA	TCGA	PFSST	DEG_SPOP_SBC_1	0.2222
p.P230Q	DO38923	THCA	ICGC	PFSST	DEG_SPOP_SBC_1	0.2222
p.N241S	SIDM00227	Neuroblastoma	GDSC	PFSST	DEG_SPOP_SBC_1	0.25
p.N241S	ACH-001344	Neuroblastoma	CCLE	PFSST	DEG_SPOP_SBC_1	0.25
p.N241S	GI-ME-N	autonomic_ganglia	COSMIC	PFSST	DEG_SPOP_SBC_1	0.25
p.V244M	SIDM01039	Other Solid Cancers	GDSC	PFSST	DEG_SPOP_SBC_1	0.1667
p.V244M	ACH-001529	Endometrial/Uterine Cancer	CCLE	PFSST	DEG_SPOP_SBC_1	0.1667
p.V244M	JAR	placenta	COSMIC	PFSST	DEG_SPOP_SBC_1	0.1667
p.P226S	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PFSST	DEG_SPOP_SBC_1	0.1111
p.P226S	ACH-000873	Esophageal Cancer	CCLE	PFSST	DEG_SPOP_SBC_1	0.1111
p.F232I	SIDM00056	Thyroid Gland Carcinoma	GDSC	PFSST	DEG_SPOP_SBC_1	0.2778
p.F232I	ACH-002148	Thyroid Cancer	CCLE	PFSST	DEG_SPOP_SBC_1	0.2778
p.F232I	K5	thyroid	COSMIC	PFSST	DEG_SPOP_SBC_1	0.2778
p.P243L	SIDM01574	Plasma Cell Myeloma	GDSC	PFSST	DEG_SPOP_SBC_1	0.1944
p.P243L	ACH-000588	Myeloma	CCLE	PFSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RUB1	Meiosis-specific coiled-coil domain-containing protein MEIOC	DEG_SPOP_SBC_1	81:85	PFSST	SPOP	0.9486	More...
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	2349:2353	PFSST	SPOP	0.9988	More...
P53804	E3 ubiquitin-protein ligase TTC3	DEG_SPOP_SBC_1	1013:1017	PFSST	SPOP	0.9797	More...
Q9UNF0	Protein kinase C and casein kinase substrate in neurons protein 2	DEG_SPOP_SBC_1	406:410	PFSST	SPOP	0.9979	More...
O75808	Calpain-15	DEG_SPOP_SBC_1	234:238	PFSST	SPOP	0.9598	More...
Q53SZ7	Proline-rich protein 30	DEG_SPOP_SBC_1	50:54	PFSST	SPOP	0.8135	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons