DegronMD

Uniprot ID: Q9UNF0

Source protein: Protein kinase C and casein kinase substrate in neurons protein 2

Source gene: PACSIN2

Class: DEG_SPOP_SBC_1

Location: 406:410

E3 ligase: SPOP

DEGRON score: 0.9979

ASA_SCORE: 52.08

COIL: 0.7766

CONS_SCORE: 0.4753

DSS_SCORE: 0.6816

HELIX: 0.1056

FCONS_SCORE: 1.0272

RIG_SCORE: 0.6274

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D397N	TCGA-BR-4370	STAD	TCGA	PFSST	DEG_SPOP_SBC_1	0.0833
p.E402Q	TCGA-CV-6961	HNSC	TCGA	PFSST	DEG_SPOP_SBC_1	0.2222
p.F419L	TCGA-KQ-A41N	BLCA	TCGA	PFSST	DEG_SPOP_SBC_1	0.0833
p.G409A	DO4963	BRCA	ICGC	PFSST	DEG_SPOP_SBC_1	0.754
p.E418K	DO5936	BRCA	ICGC	PFSST	DEG_SPOP_SBC_1	0.1111
p.D420V	DO233784	GACA	ICGC	PFSST	DEG_SPOP_SBC_1	0.0556
p.T396N	DO228948	LICA	ICGC	PFSST	DEG_SPOP_SBC_1	0.5
p.N405K	DO228985	LICA	ICGC	PFSST	DEG_SPOP_SBC_1	0.3056
p.P418S	DO222843	MELA	ICGC	PFSST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RUB1	Meiosis-specific coiled-coil domain-containing protein MEIOC	DEG_SPOP_SBC_1	81:85	PFSST	SPOP	0.9486	More...
O95359	Transforming acidic coiled-coil-containing protein 2	DEG_SPOP_SBC_1	2349:2353	PFSST	SPOP	0.9988	More...
P53804	E3 ubiquitin-protein ligase TTC3	DEG_SPOP_SBC_1	1013:1017	PFSST	SPOP	0.9797	More...
Q9UNF0	Protein kinase C and casein kinase substrate in neurons protein 2	DEG_SPOP_SBC_1	406:410	PFSST	SPOP	0.9979	More...
O75808	Calpain-15	DEG_SPOP_SBC_1	234:238	PFSST	SPOP	0.9598	More...
Q53SZ7	Proline-rich protein 30	DEG_SPOP_SBC_1	50:54	PFSST	SPOP	0.8135	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons