DegronMD

Uniprot ID: Q8NG31

Source protein: Kinetochore scaffold 1

Source gene: KNL1

Class: DEG_SCF_FBW7_2

Location: 1014:1021

E3 ligase: FBXW7

DEGRON score: 0.9775

ASA_SCORE: 84.1625

COIL: 0.6904

CONS_SCORE: 0.2659

DSS_SCORE: 0.4798

HELIX: 0.0568

FCONS_SCORE: 0.6941

RIG_SCORE: 0.7755

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1022I	SIDM00698	Small Cell Lung Carcinoma	GDSC	VICTPTEE	DEG_SCF_FBW7_2	0.3056
p.S1022I	NCI-H146	lung	COSMIC	VICTPTEE	DEG_SCF_FBW7_2	0.3056
p.R1006K	SIDM00571	Pancreatic Carcinoma	GDSC	VICTPTEE	DEG_SCF_FBW7_2	0.1111
p.R1006K	KP-3	pancreas	COSMIC	VICTPTEE	DEG_SCF_FBW7_2	0.1111
p.S1008N	SIDM00493	Other Solid Cancers	GDSC	VICTPTEE	DEG_SCF_FBW7_2	0.6111
p.S1013N	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	VICTPTEE	DEG_SCF_FBW7_2	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NG31	Kinetochore scaffold 1	DEG_SCF_FBW7_2	1014:1021	VICTPTEE	FBXW7	0.9775	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons