DegronMD

Uniprot ID: Q8NG31

Source protein: Kinetochore scaffold 1

Source gene: KNL1

Class: DEG_SCF_FBW7_2

Location: 538:543

E3 ligase: FBXW7

DEGRON score: 0.8912

ASA_SCORE: 99.25

COIL: 0.64

CONS_SCORE: 0.3779

DSS_SCORE: 0.5083

HELIX: 0.3028

FCONS_SCORE: 1.0351

RIG_SCORE: 0.7558

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M550T	SIDM00457	Plasma Cell Myeloma	GDSC	PTPEKE	DEG_SCF_FBW7_2	0.1389
p.M550T	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	PTPEKE	DEG_SCF_FBW7_2	0.1389
p.M550T	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PTPEKE	DEG_SCF_FBW7_2	0.1389
p.M550T	TE-5	oesophagus	COSMIC	PTPEKE	DEG_SCF_FBW7_2	0.1389
p.H541Y	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	PTPEKE	DEG_SCF_FBW7_2	0.7229

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NG31	Kinetochore scaffold 1	DEG_SCF_FBW7_2	538:543	PTPEKE	FBXW7	0.8912	More...
Q9BQI3	Eukaryotic translation initiation factor 2-alpha kinase 1	DEG_SCF_FBW7_2	284:289	PTPEKE	FBXW7	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons