DegronMD

Uniprot ID: Q9BQI3

Source protein: Eukaryotic translation initiation factor 2-alpha kinase 1

Source gene: EIF2AK1

Class: DEG_SCF_FBW7_2

Location: 284:289

E3 ligase: FBXW7

DEGRON score: 0.9961

ASA_SCORE: 77.75

COIL: 0.6902

CONS_SCORE: 0.3528

DSS_SCORE: 0.6282

HELIX: 0.2713

FCONS_SCORE: 1.0169

RIG_SCORE: 0.6647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R291C	TCGA-50-6594	LUAD	TCGA	PTPEKE	DEG_SCF_FBW7_2	0.2778
p.E294K	TCGA-AN-A046	BRCA	TCGA	PTPEKE	DEG_SCF_FBW7_2	0.1944
p.E294K	TCGA-GD-A3OP	BLCA	TCGA	PTPEKE	DEG_SCF_FBW7_2	0.1944
p.R291H	TCGA-AP-A0LM	UCEC	TCGA	PTPEKE	DEG_SCF_FBW7_2	0.2778
p.S277A	TCGA-B5-A1MR	UCEC	TCGA	PTPEKE	DEG_SCF_FBW7_2	0.1389
p.S278F	TCGA-EE-A29N	SKCM	TCGA	PTPEKE	DEG_SCF_FBW7_2	0.1667
p.S276C	TCGA-UF-A7J9	HNSC	TCGA	PTPEKE	DEG_SCF_FBW7_2	0.5556
p.A286T	DO1608	BRCA	ICGC	PTPEKE	DEG_SCF_FBW7_2	0.7139
p.R279W	DO233737	GACA	ICGC	PTPEKE	DEG_SCF_FBW7_2	0.1944
p.R277W	DO233889	GACA	ICGC	PTPEKE	DEG_SCF_FBW7_2	0.1389
p.T296A	DO15006	HNSC	ICGC	PTPEKE	DEG_SCF_FBW7_2	0.1389
p.N275K	DO228985	LICA	ICGC	PTPEKE	DEG_SCF_FBW7_2	0.5278
p.R277L	DO230982	LUSC	ICGC	PTPEKE	DEG_SCF_FBW7_2	0.1389
p.R277L	DO224613	LUSC	ICGC	PTPEKE	DEG_SCF_FBW7_2	0.1389
p.E284K	DO219136	LUSC	ICGC	PTPEKE	DEG_SCF_FBW7_2	0.7022
p.S285Y	DO232224	PBCA	ICGC	PTPEKE	DEG_SCF_FBW7_2	0.712
p.P288S	DO47419	SKCM	ICGC	PTPEKE	DEG_SCF_FBW7_2	0.6752
p.E280D	DO42665	UCEC	ICGC	PTPEKE	DEG_SCF_FBW7_2	0.2222
p.S276R	SIDM00938	Breast Carcinoma	GDSC	PTPEKE	DEG_SCF_FBW7_2	0.5556
p.S276R	ACH-000902	Breast Cancer	CCLE	PTPEKE	DEG_SCF_FBW7_2	0.5556
p.S276R	CAL-148	breast	COSMIC	PTPEKE	DEG_SCF_FBW7_2	0.5556
p.T297A	SIDM01013	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPEKE	DEG_SCF_FBW7_2	0.5556
p.T297A	ACH-000106	Lymphoma	CCLE	PTPEKE	DEG_SCF_FBW7_2	0.5556
p.T297A	JVM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PTPEKE	DEG_SCF_FBW7_2	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NG31	Kinetochore scaffold 1	DEG_SCF_FBW7_2	538:543	PTPEKE	FBXW7	0.8912	More...
Q9BQI3	Eukaryotic translation initiation factor 2-alpha kinase 1	DEG_SCF_FBW7_2	284:289	PTPEKE	FBXW7	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons