DegronMD

Uniprot ID: Q8NG31

Source protein: Kinetochore scaffold 1

Source gene: KNL1

Class: DEG_SPOP_SBC_1

Location: 1656:1660

E3 ligase: SPOP

DEGRON score: 0.9488

ASA_SCORE: 88.82

COIL: 0.7686

CONS_SCORE: 0.339

DSS_SCORE: 0.6015

HELIX: 0.024

FCONS_SCORE: 1.0494

RIG_SCORE: 0.6264

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1670R	SIDM00971	Breast Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.1667
p.K1670R	SIDM00032	Bladder Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.1667
p.K1670R	SIDM00807	Bladder Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.1667
p.K1670R	SIDM00793	Burkitt's Lymphoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.1667
p.K1670R	SIDM00863	Burkitt's Lymphoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.1667
p.K1670R	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.1667
p.T1665S	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.1944
p.T1665S	NCI-H1755	lung	COSMIC	AETTS	DEG_SPOP_SBC_1	0.1944
p.T1659A	SIDM01608	Endometrial Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PIF2	Synaptonemal complex central element protein 2	DEG_SPOP_SBC_1	199:203	AETTS	SPOP	0.8896	More...
Q8NG31	Kinetochore scaffold 1	DEG_SPOP_SBC_1	1656:1660	AETTS	SPOP	0.9488	More...
Q92750	Transcription initiation factor TFIID subunit 4B	DEG_SPOP_SBC_1	138:142	AETTS	SPOP	0.9872	More...
Q96PE2	Rho guanine nucleotide exchange factor 17	DEG_SPOP_SBC_1	1677:1681	AETTS	SPOP	0.9496	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons