DegronMD

Uniprot ID: Q96PE2

Source protein: Rho guanine nucleotide exchange factor 17

Source gene: ARHGEF17

Class: DEG_SPOP_SBC_1

Location: 1677:1681

E3 ligase: SPOP

DEGRON score: 0.9496

ASA_SCORE: 85.66

COIL: 0.8128

CONS_SCORE: 0.4278

DSS_SCORE: 0.8527

HELIX: 0.1254

FCONS_SCORE: 1.0914

RIG_SCORE: 0.6413

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1683Q	TCGA-CR-6484	HNSC	TCGA	AETTS	DEG_SPOP_SBC_1	0.2778
p.E1683Q	DO15206	HNSC	ICGC	AETTS	DEG_SPOP_SBC_1	0.2778
p.A1677T	TCGA-D5-6540	COAD	TCGA	AETTS	DEG_SPOP_SBC_1	0.7139
p.A1677T	DO9708	COAD	ICGC	AETTS	DEG_SPOP_SBC_1	0.7139
p.A1677T	DO41199	UCEC	ICGC	AETTS	DEG_SPOP_SBC_1	0.7139
p.G1689C	DO227802	COCA	ICGC	AETTS	DEG_SPOP_SBC_1	0.1111
p.P1670L	SIDM01609	Endometrial Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.1389
p.P1670L	ACH-000972	Endometrial/Uterine Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	0.1389
p.E1684K	SIDM01750	Melanoma	GDSC	AETTS	DEG_SPOP_SBC_1	0.25
p.E1684K	ACH-000801	Skin Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PIF2	Synaptonemal complex central element protein 2	DEG_SPOP_SBC_1	199:203	AETTS	SPOP	0.8896	More...
Q8NG31	Kinetochore scaffold 1	DEG_SPOP_SBC_1	1656:1660	AETTS	SPOP	0.9488	More...
Q92750	Transcription initiation factor TFIID subunit 4B	DEG_SPOP_SBC_1	138:142	AETTS	SPOP	0.9872	More...
Q96PE2	Rho guanine nucleotide exchange factor 17	DEG_SPOP_SBC_1	1677:1681	AETTS	SPOP	0.9496	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons