DegronMD - Q96PE2(ARHGEF17)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L537F	TCGA-55-8616	LUAD	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.6981
p.L537F	DO23566	LUAD	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.6981
p.T538I	TCGA-A5-A1OF	UCEC	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.5966
p.T538I	DO42568	UCEC	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.5966
p.R1715C	TCGA-A5-A2K3	UCEC	TCGA	TRGSLEDLL	DEG_APCC_DBOX_1	1722:1730	Mutation rewiring degron network	0.1389
p.R1715C	DO43899	UCEC	ICGC	TRGSLEDLL	DEG_APCC_DBOX_1	1722:1730	Mutation rewiring degron network	0.1389
p.T530M	TCGA-A6-6780	COAD	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.7423
p.T530M	TCGA-XK-AAIW	PRAD	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.7423
p.T530M	DO10244	COAD	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.7423
p.T530M	DO51407	PRAD	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.7423
p.T530M	SIDM00660	Colorectal Carcinoma	GDSC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.7423
p.T530M	ACH-000985	Colon/Colorectal Cancer	CCLE	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.7423
p.T530M	LS-411N	large intestine	COSMIC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.7423
p.G1719S	TCGA-AX-A2HJ	UCEC	TCGA	TRGSLEDLL	DEG_APCC_DBOX_1	1722:1730	Mutation rewiring degron network	0.25
p.G1719S	DO42105	UCEC	ICGC	TRGSLEDLL	DEG_APCC_DBOX_1	1722:1730	Mutation rewiring degron network	0.25
p.G1719S	SIDM00625	Other Sarcomas	GDSC	TRGSLEDLL	DEG_APCC_DBOX_1	1722:1730	Mutation rewiring degron network	0.25
p.G1719S	SIDM00507	Other Solid Cancers	GDSC	TRGSLEDLL	DEG_APCC_DBOX_1	1722:1730	Mutation rewiring degron network	0.25
p.G1719S	SIDM01711	Non-Cancerous	GDSC	TRGSLEDLL	DEG_APCC_DBOX_1	1722:1730	Mutation rewiring degron network	0.25
p.E863K	TCGA-BH-A0HY	BRCA	TCGA	PPSSS	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.3056
p.L541M	TCGA-BR-8078	STAD	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.25
p.L541M	DO231102	LUSC	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.25
p.L541M	DO38288	STAD	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.25
p.R542Q	TCGA-BR-8591	STAD	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.2222
p.R542Q	TCGA-Q1-A73R	CESC	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.2222
p.R542Q	DO49984	CESC	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.2222
p.R542Q	DO47973	STAD	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.2222
p.P523T	TCGA-CK-4951	COAD	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.1389
p.P523T	DO10582	COAD	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.1389
p.E1683Q	TCGA-CR-6484	HNSC	TCGA	AETTS	DEG_SPOP_SBC_1	1677:1681	Mutation rewiring degron network	0.2778
p.E1683Q	DO15206	HNSC	ICGC	AETTS	DEG_SPOP_SBC_1	1677:1681	Mutation rewiring degron network	0.2778
p.T665I	TCGA-D1-A174	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation rewiring degron network	0.1944
p.T665I	DO40900	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation rewiring degron network	0.1944
p.A1677T	TCGA-D5-6540	COAD	TCGA	AETTS	DEG_SPOP_SBC_1	1677:1681	Mutation altering degron motif	0.7139
p.A1677T	DO9708	COAD	ICGC	AETTS	DEG_SPOP_SBC_1	1677:1681	Mutation altering degron motif	0.7139
p.A1677T	DO41199	UCEC	ICGC	AETTS	DEG_SPOP_SBC_1	1677:1681	Mutation altering degron motif	0.7139
p.A539V	TCGA-D6-6516	HNSC	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.3056
p.A539V	DO15623	HNSC	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.3056
p.P683S	TCGA-D6-6516	HNSC	TCGA	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation rewiring degron network	0.0833
p.P683S	DO15623	HNSC	ICGC	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation rewiring degron network	0.0833
p.P849L	TCGA-DD-A1EE	LIHC	TCGA	PPSSS	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.0833
p.P849L	TCGA-G3-A25S	LIHC	TCGA	PPSSS	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.0833
p.P849L	DO23018	LIHC	ICGC	PPSSS	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.0833
p.P849L	DO22857	LIHC	ICGC	PPSSS	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.0833
p.P528T	TCGA-DF-A2KN	UCEC	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.2778
p.P528T	DO223282	UCEC	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.2778
p.R542L	TCGA-EE-A2GH	SKCM	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.2222
p.R542L	DO37643	SKCM	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.2222
p.G682S	TCGA-ER-A3PL	SKCM	TCGA	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation rewiring degron network	0.1111
p.G682S	DO37495	SKCM	ICGC	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation rewiring degron network	0.1111
p.E848K	TCGA-FR-A726	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.0556
p.E848K	DO48665	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.0556
p.R531C	TCGA-SS-A7HO	COAD	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.8301
p.R531C	DO223705	COAD	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.8301
p.S250Y	DO225079	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	247:251	Mutation altering degron motif	0.712
p.R870Q	DO230312	COCA	ICGC	PPSSS	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.1111
p.G1689C	DO227802	COCA	ICGC	AETTS	DEG_SPOP_SBC_1	1677:1681	Mutation rewiring degron network	0.1111
p.R246G	DO234297	ESAD	ICGC	AASSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.3056
p.A871S	DO228952	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.0833
p.R1715L	DO229028	LICA	ICGC	TRGSLEDLL	DEG_APCC_DBOX_1	1722:1730	Mutation rewiring degron network	0.1389
p.S249G	DO232761	PBCA	ICGC	AASSS	DEG_SPOP_SBC_1	247:251	Mutation altering degron motif	0.6993
p.A1736T	DO232761	PBCA	ICGC	TRGSLEDLL	DEG_APCC_DBOX_1	1722:1730	Mutation rewiring degron network	0.1667
p.S239F	DO234001	THCA	ICGC	AASSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1111
p.R851Q	SIDM01943	Colorectal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.1389
p.R851Q	ACH-001786	Colon/Colorectal Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.1389
p.S239Y	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1111
p.S239Y	SIDM00773	Non-Cancerous	GDSC	AASSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1111
p.S239Y	SIDM00948	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1111
p.S239Y	SIDM00907	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1111
p.S239Y	SIDM00774	Breast Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1111
p.S239Y	SIDM01594	Breast Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1111
p.A238S	SIDM00845	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.0833
p.G257D	SIDM00516	Melanoma	GDSC	AASSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.G257D	ACH-002166	Skin Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.G257D	MZ7-mel	skin	COSMIC	AASSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.1667
p.R542W	SIDM00214	Colorectal Carcinoma	GDSC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.2222
p.R542W	ACH-000955	Colon/Colorectal Cancer	CCLE	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.2222
p.R542W	SNU-407	large intestine	COSMIC	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.2222
p.P670L	SIDM00940	Breast Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation altering degron motif	0.7582
p.P670L	CAL-120	breast	COSMIC	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation altering degron motif	0.7582
p.G682D	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation rewiring degron network	0.1111
p.G682D	ACH-001127	Leukemia	CCLE	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation rewiring degron network	0.1111
p.G682D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation rewiring degron network	0.1111
p.R669Q	SIDM00045	Gastric Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation rewiring degron network	0.3056
p.R669Q	ACH-002141	Gastric Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation rewiring degron network	0.3056
p.R669Q	HSC-39	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation rewiring degron network	0.3056
p.P670S	SIDM00540	Oral Cavity Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation altering degron motif	0.6752
p.P670S	ACH-001864	Bile Duct Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation altering degron motif	0.6752
p.P670S	ACH-002234	Head and Neck Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation altering degron motif	0.6752
p.P670S	DOK	upper aerodigestive tract	COSMIC	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation altering degron motif	0.6752
p.P1670L	SIDM01609	Endometrial Carcinoma	GDSC	AETTS	DEG_SPOP_SBC_1	1677:1681	Mutation rewiring degron network	0.1389
p.P1670L	ACH-000972	Endometrial/Uterine Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	1677:1681	Mutation rewiring degron network	0.1389
p.A676T	SIDM01622	Breast Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation rewiring degron network	0.2778
p.A676T	ACH-000721	Breast Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	670:674	Mutation rewiring degron network	0.2778
p.E1684K	SIDM01750	Melanoma	GDSC	AETTS	DEG_SPOP_SBC_1	1677:1681	Mutation rewiring degron network	0.25
p.E1684K	ACH-000801	Skin Cancer	CCLE	AETTS	DEG_SPOP_SBC_1	1677:1681	Mutation rewiring degron network	0.25
p.L537W	ACH-000894	Lung Cancer	CCLE	TRPTLKDLT	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.7015
p.V867I	ACH-001431	Bone Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	858:862	Mutation rewiring degron network	0.1944
p.E243K	NCI-H2110	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.2222
p.R244H	PF-382	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	247:251	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF17

UniProt ID: Q96PE2

Entrez ID: 9828

Protein name: Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGEF17 in