DegronMD

Uniprot ID: Q96PE2

Source protein: Rho guanine nucleotide exchange factor 17

Source gene: ARHGEF17

Class: DEG_APCC_DBOX_1

Location: 1722:1730

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8342

ASA_SCORE: 76.8

COIL: 0.6223

CONS_SCORE: 0.3588

DSS_SCORE: 0.4177

HELIX: 0.2653

FCONS_SCORE: 0.9583

RIG_SCORE: 0.7395

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1715C	TCGA-A5-A2K3	UCEC	TCGA	TRGSLEDLL	DEG_APCC_DBOX_1	0.1389
p.R1715C	DO43899	UCEC	ICGC	TRGSLEDLL	DEG_APCC_DBOX_1	0.1389
p.G1719S	TCGA-AX-A2HJ	UCEC	TCGA	TRGSLEDLL	DEG_APCC_DBOX_1	0.25
p.G1719S	DO42105	UCEC	ICGC	TRGSLEDLL	DEG_APCC_DBOX_1	0.25
p.G1719S	SIDM00625	Other Sarcomas	GDSC	TRGSLEDLL	DEG_APCC_DBOX_1	0.25
p.G1719S	SIDM00507	Other Solid Cancers	GDSC	TRGSLEDLL	DEG_APCC_DBOX_1	0.25
p.G1719S	SIDM01711	Non-Cancerous	GDSC	TRGSLEDLL	DEG_APCC_DBOX_1	0.25
p.R1715L	DO229028	LICA	ICGC	TRGSLEDLL	DEG_APCC_DBOX_1	0.1389
p.A1736T	DO232761	PBCA	ICGC	TRGSLEDLL	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PE2	Rho guanine nucleotide exchange factor 17	DEG_APCC_DBOX_1	1722:1730	TRGSLEDLL	APC,CDC20,FZR1	0.8342	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons