DegronMD

Uniprot ID: Q96PE2

Source protein: Rho guanine nucleotide exchange factor 17

Source gene: ARHGEF17

Class: DEG_APCC_DBOX_1

Location: 530:538

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9897

ASA_SCORE: 61.9

COIL: 0.4037

CONS_SCORE: 0.4017

DSS_SCORE: 0.6295

HELIX: 0.5722

FCONS_SCORE: 1.108

RIG_SCORE: 0.7261

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L537F	TCGA-55-8616	LUAD	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	0.6981
p.L537F	DO23566	LUAD	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	0.6981
p.T538I	TCGA-A5-A1OF	UCEC	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	0.5966
p.T538I	DO42568	UCEC	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	0.5966
p.T530M	TCGA-A6-6780	COAD	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	0.7423
p.T530M	TCGA-XK-AAIW	PRAD	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	0.7423
p.T530M	DO10244	COAD	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	0.7423
p.T530M	DO51407	PRAD	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	0.7423
p.T530M	SIDM00660	Colorectal Carcinoma	GDSC	TRPTLKDLT	DEG_APCC_DBOX_1	0.7423
p.T530M	ACH-000985	Colon/Colorectal Cancer	CCLE	TRPTLKDLT	DEG_APCC_DBOX_1	0.7423
p.T530M	LS-411N	large_intestine	COSMIC	TRPTLKDLT	DEG_APCC_DBOX_1	0.7423
p.L541M	TCGA-BR-8078	STAD	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	0.25
p.L541M	DO231102	LUSC	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	0.25
p.L541M	DO38288	STAD	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	0.25
p.R542Q	TCGA-BR-8591	STAD	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	0.2222
p.R542Q	TCGA-Q1-A73R	CESC	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	0.2222
p.R542Q	DO49984	CESC	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	0.2222
p.R542Q	DO47973	STAD	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	0.2222
p.P523T	TCGA-CK-4951	COAD	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	0.1389
p.P523T	DO10582	COAD	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	0.1389
p.A539V	TCGA-D6-6516	HNSC	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	0.3056
p.A539V	DO15623	HNSC	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	0.3056
p.P528T	TCGA-DF-A2KN	UCEC	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	0.2778
p.P528T	DO223282	UCEC	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	0.2778
p.R542L	TCGA-EE-A2GH	SKCM	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	0.2222
p.R542L	DO37643	SKCM	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	0.2222
p.R531C	TCGA-SS-A7HO	COAD	TCGA	TRPTLKDLT	DEG_APCC_DBOX_1	0.8301
p.R531C	DO223705	COAD	ICGC	TRPTLKDLT	DEG_APCC_DBOX_1	0.8301
p.R542W	SIDM00214	Colorectal Carcinoma	GDSC	TRPTLKDLT	DEG_APCC_DBOX_1	0.2222
p.R542W	ACH-000955	Colon/Colorectal Cancer	CCLE	TRPTLKDLT	DEG_APCC_DBOX_1	0.2222
p.R542W	SNU-407	large_intestine	COSMIC	TRPTLKDLT	DEG_APCC_DBOX_1	0.2222
p.L537W	ACH-000894	Lung Cancer	CCLE	TRPTLKDLT	DEG_APCC_DBOX_1	0.7015

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRPTLKDLT

Degron related mutations and impact score

Drug responses associated with ARHGEF17 mutations

All proteins holding degron of TRPTLKDLT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PE2	Rho guanine nucleotide exchange factor 17	DEG_APCC_DBOX_1	530:538	TRPTLKDLT	APC,CDC20,FZR1	0.9897	More...