DegronMD

Uniprot ID: Q8NG31

Source protein: Kinetochore scaffold 1

Source gene: KNL1

Class: DEG_APCC_DBOX_1

Location: 30:38

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9971

ASA_SCORE: 81.4222

COIL: 0.7247

CONS_SCORE: 0.4899

DSS_SCORE: 0.6828

HELIX: 0.2003

FCONS_SCORE: 1.1733

RIG_SCORE: 0.624

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P30L	SIDM00179	Melanoma	GDSC	PRSPLQDLR	DEG_APCC_DBOX_1	0.6471
p.R22W	SIDM00667	Other Sarcomas	GDSC	PRSPLQDLR	DEG_APCC_DBOX_1	0.1111
p.N41D	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PRSPLQDLR	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NG31	Kinetochore scaffold 1	DEG_APCC_DBOX_1	30:38	PRSPLQDLR	APC,CDC20,FZR1	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons