DegronMD

Uniprot ID: Q8NG31

Source protein: Kinetochore scaffold 1

Source gene: KNL1

Class: DEG_SCF_TRCP1_1

Location: 1719:1724

E3 ligase: BTRC

DEGRON score: 0.9854

ASA_SCORE: 66.6167

COIL: 0.8397

CONS_SCORE: 0.3698

DSS_SCORE: 0.4904

HELIX: 0.0773

FCONS_SCORE: 0.8861

RIG_SCORE: 0.633

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1717L	CW-2	large_intestine	COSMIC	DSGIGS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5D1E8	Endoribonuclease ZC3H12A	DEG_SCF_TRCP1_1	437:442	DSGIGS	BTRC	0.9148	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SCF_TRCP1_1	1793:1798	DSGIGS	BTRC	0.9953	More...
Q8NG31	Kinetochore scaffold 1	DEG_SCF_TRCP1_1	1719:1724	DSGIGS	BTRC	0.9854	More...
Q5VUJ6	Leucine-rich repeat and calponin homology domain-containing protein 2	DEG_SCF_TRCP1_1	346:351	DSGIGS	BTRC	0.9491	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons