DegronMD

Uniprot ID: Q5D1E8

Source protein: Endoribonuclease ZC3H12A

Source gene: ZC3H12A

Class: DEG_SCF_TRCP1_1

Location: 437:442

E3 ligase: BTRC

DEGRON score: 0.9148

ASA_SCORE: 49

COIL: 0.8393

CONS_SCORE: 0.4137

DSS_SCORE: 0.4419

HELIX: 0.1333

FCONS_SCORE: 0.9557

RIG_SCORE: 0.7147

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G439D	TCGA-06-0130	GBM	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.7198
p.G439D	DO12052	GBM	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.7198
p.S442P	TCGA-C5-A1MJ	CESC	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.6752
p.S442P	DO49017	CESC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.6752
p.D434V	TCGA-CD-A4MG	STAD	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.25
p.D434V	DO48009	STAD	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.25
p.S438L	TCGA-D1-A17Q	UCEC	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.7667
p.S438L	TCGA-EO-A22R	UCEC	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.7667
p.S438L	DO41903	UCEC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.7667
p.S438L	DO42713	UCEC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.7667
p.L450F	TCGA-EI-6883	READ	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.1111
p.L450F	DO36443	READ	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.1111
p.E449Q	TCGA-GD-A76B	BLCA	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.1389
p.E449Q	DO51886	BLCA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.1389
p.S448L	TCGA-IB-7651	PAAD	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.1667
p.S448L	DO46657	PAAD	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.1667
p.M447I	DO229006	LICA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.1944
p.G439S	SIDM00477	Esophageal Carcinoma	GDSC	DSGIGS	DEG_SCF_TRCP1_1	0.6993
p.G439S	ACH-000383	Esophageal Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	0.6993
p.G439S	OE33	oesophagus	COSMIC	DSGIGS	DEG_SCF_TRCP1_1	0.6993
p.L436M	SIDM01619	Endometrial Carcinoma	GDSC	DSGIGS	DEG_SCF_TRCP1_1	0.3056
p.L436M	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	0.3056
p.M447R	ACH-001001	Bone Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5D1E8	Endoribonuclease ZC3H12A	DEG_SCF_TRCP1_1	437:442	DSGIGS	BTRC	0.9148	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SCF_TRCP1_1	1793:1798	DSGIGS	BTRC	0.9953	More...
Q8NG31	Kinetochore scaffold 1	DEG_SCF_TRCP1_1	1719:1724	DSGIGS	BTRC	0.9854	More...
Q5VUJ6	Leucine-rich repeat and calponin homology domain-containing protein 2	DEG_SCF_TRCP1_1	346:351	DSGIGS	BTRC	0.9491	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons