DegronMD

Uniprot ID: Q5VUJ6

Source protein: Leucine-rich repeat and calponin homology domain-containing protein 2

Source gene: LRCH2

Class: DEG_SCF_TRCP1_1

Location: 346:351

E3 ligase: BTRC

DEGRON score: 0.9491

ASA_SCORE: 37.1333

COIL: 0.7212

CONS_SCORE: 0.4764

DSS_SCORE: 0.7189

HELIX: 0.0545

FCONS_SCORE: 1.0361

RIG_SCORE: 0.5463

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N353Y	TCGA-58-A46M	LUSC	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.2778
p.N353Y	DO45485	LUSC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.2778
p.N342K	TCGA-AG-A015	READ	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.2222
p.K341N	TCGA-B5-A11N	UCEC	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.3056
p.K341N	DO41458	UCEC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.3056
p.Y338C	TCGA-EO-A22R	UCEC	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.1111
p.Y338C	DO42713	UCEC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.1111
p.N353T	DO227849	COCA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.2778
p.G344C	DO23276	LINC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.2778
p.G344V	DO23276	LINC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.2778
p.D352G	DO229253	THCA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.3056
p.E355V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	DSGIGS	DEG_SCF_TRCP1_1	0.2222
p.E355V	ACH-000924	Lung Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	0.2222
p.E355V	NCI-H2172	lung	COSMIC	DSGIGS	DEG_SCF_TRCP1_1	0.2222
p.D346E	SIDM01056	Breast Carcinoma	GDSC	DSGIGS	DEG_SCF_TRCP1_1	0.6758
p.D346E	ACH-000330	Breast Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	0.6758
p.D346E	EFM-19	breast	COSMIC	DSGIGS	DEG_SCF_TRCP1_1	0.6758
p.G350E	SIDM01133	Other Solid Cancers	GDSC	DSGIGS	DEG_SCF_TRCP1_1	0.6087
p.G350E	ACH-002177	Lung Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	0.6087
p.G350E	NCI-H835	lung	COSMIC	DSGIGS	DEG_SCF_TRCP1_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5D1E8	Endoribonuclease ZC3H12A	DEG_SCF_TRCP1_1	437:442	DSGIGS	BTRC	0.9148	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SCF_TRCP1_1	1793:1798	DSGIGS	BTRC	0.9953	More...
Q8NG31	Kinetochore scaffold 1	DEG_SCF_TRCP1_1	1719:1724	DSGIGS	BTRC	0.9854	More...
Q5VUJ6	Leucine-rich repeat and calponin homology domain-containing protein 2	DEG_SCF_TRCP1_1	346:351	DSGIGS	BTRC	0.9491	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons