DegronMD - Q7Z7G8(VPS13B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1795V	TCGA-06-1802	GBM	TCGA	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation altering degron motif	0.7532
p.G1795V	DO12100	GBM	ICGC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation altering degron motif	0.7532
p.R1200G	TCGA-2G-AAKL	TGCT	TCGA	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation rewiring degron network	0.1944
p.G1196E	TCGA-49-4487	LUAD	TCGA	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation rewiring degron network	0.0833
p.G1196E	DO24780	LUAD	ICGC	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation rewiring degron network	0.0833
p.I1808R	TCGA-AA-3956	COAD	TCGA	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.0556
p.R146Q	TCGA-AA-A010	COAD	TCGA	PPGY	ITCH	136:139	Mutation rewiring degron network	0.1389
p.R146Q	TCGA-QC-A7B5	SARC	TCGA	PPGY	ITCH	136:139	Mutation rewiring degron network	0.1389
p.R146Q	DO220239	SARC	ICGC	PPGY	ITCH	136:139	Mutation rewiring degron network	0.1389
p.C1279Y	TCGA-AP-A051	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.3056
p.C1279Y	DO42673	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.3056
p.T1195A	TCGA-AR-A2LN	BRCA	TCGA	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation blocking phosphorylation signal	0.5
p.T1195A	DO4197	BRCA	ICGC	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation blocking phosphorylation signal	0.5
p.G1797C	TCGA-CK-5913	COAD	TCGA	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation altering degron motif	0.6489
p.G1797C	DO8826	COAD	ICGC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation altering degron motif	0.6489
p.R1804T	TCGA-DS-A0VM	CESC	TCGA	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.1667
p.A1272T	TCGA-DU-6392	LGG	TCGA	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.2778
p.A1272T	DO22237	LGG	ICGC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.2778
p.A1272T	SIDM01307	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.2778
p.P1264S	TCGA-EE-A2A2	SKCM	TCGA	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.0556
p.P1264S	DO37583	SKCM	ICGC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.0556
p.R1200Q	TCGA-EO-A22R	UCEC	TCGA	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation rewiring degron network	0.1944
p.R1200Q	DO42713	UCEC	ICGC	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation rewiring degron network	0.1944
p.R1200Q	ACH-001687	Kidney Cancer	CCLE	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation rewiring degron network	0.1944
p.S1219C	TCGA-VQ-A8PM	STAD	TCGA	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation rewiring degron network	0.0833
p.S1219C	DO51772	STAD	ICGC	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation rewiring degron network	0.0833
p.P1264A	TCGA-XF-AAN3	BLCA	TCGA	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.0556
p.P1264A	DO219053	BLCA	ICGC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.0556
p.V1801F	TCGA-YD-A9TA	SKCM	TCGA	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.25
p.R1799G	DO225390	BRCA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.3056
p.I1783R	DO9700	COAD	ICGC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.0556
p.P130H	DO222492	COCA	ICGC	PPGY	ITCH	136:139	Mutation rewiring degron network	0.1667
p.S1213L	DO234469	ESAD	ICGC	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation rewiring degron network	0.25
p.P1274L	DO233797	GACA	ICGC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation altering degron motif	0.7582
p.C1206Y	DO233814	GACA	ICGC	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation altering degron motif	0.5976
p.Q1791H	DO14830	HNSC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.2778
p.E1784D	DO228974	LICA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.0833
p.V1804L	DO229029	LICA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.1667
p.V1209F	DO229026	LICA	ICGC	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation altering degron motif	0.5957
p.S1800I	DO229036	LICA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation blocking phosphorylation signal	0.7222
p.C1218F	DO229045	LICA	ICGC	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation rewiring degron network	0.1111
p.E1784Q	DO45475	LUSC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.0833
p.I1269V	DO49116	PACA	ICGC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.1944
p.R1787C	SIDM02075	Colorectal Carcinoma	GDSC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.1667
p.R1787C	SIDM00221	Melanoma	GDSC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.1667
p.R1787C	SIDM01588	Endometrial Carcinoma	GDSC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.1667
p.R1787C	ACH-000855	Esophageal Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.1667
p.R1787C	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.1667
p.R1787C	ACH-002388	Skin Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.1667
p.S1219F	SIDM00113	Kidney Carcinoma	GDSC	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation rewiring degron network	0.0833
p.S1219F	ACH-001208	Kidney Cancer	CCLE	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation rewiring degron network	0.0833
p.S1219F	TK10	kidney	COSMIC	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation rewiring degron network	0.0833
p.T1276I	SIDM00928	Breast Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation altering degron motif	0.7078
p.T1276I	CAL-85-1	breast	COSMIC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation altering degron motif	0.7078
p.P1264T	SIDM00562	Breast Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.0556
p.P1264T	ACH-002163	Breast Cancer	CCLE	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.0556
p.P1264T	MRK-nu-1	breast	COSMIC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.0556
p.T1271S	SIDM00710	Small Cell Lung Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.25
p.A128S	SIDM01611	Endometrial Carcinoma	GDSC	PPGY	ITCH	136:139	Mutation rewiring degron network	0.1111
p.A128S	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPGY	ITCH	136:139	Mutation rewiring degron network	0.1111
p.D1793H	ACH-000831	Endometrial/Uterine Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation altering degron motif	0.7688
p.T1784N	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VPS13B

UniProt ID: Q7Z7G8

Entrez ID: 157680

Protein name: Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VPS13B in