DegronMD - Q7Z7G8(VPS13B)

FUNCTION: Mediates the transfer of lipids between membranes at organelle contact sites. {ECO:0000250|UniProtKB:Q07878}.

GO - Biological processes (BP): protein transport [GO:0015031]

GO - Molecular function (MF):

GO - Cellular component (CC):

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1793H	ACH-000831	Endometrial/Uterine Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation altering degron motif	0.7688
p.P1274L	DO233797	GACA	ICGC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation altering degron motif	0.7582
p.G1795V	TCGA-06-1802	GBM	TCGA	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation altering degron motif	0.7532
p.G1795V	DO12100	GBM	ICGC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation altering degron motif	0.7532
p.S1800I	DO229036	LICA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation blocking phosphorylation signal	0.7222
p.T1276I	SIDM00928	Breast Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation altering degron motif	0.7078
p.T1276I	CAL-85-1	breast	COSMIC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation altering degron motif	0.7078
p.G1797C	TCGA-CK-5913	COAD	TCGA	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation altering degron motif	0.6489
p.G1797C	DO8826	COAD	ICGC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation altering degron motif	0.6489
p.C1206Y	DO233814	GACA	ICGC	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation altering degron motif	0.5976
p.V1209F	DO229026	LICA	ICGC	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation altering degron motif	0.5957
p.T1195A	TCGA-AR-A2LN	BRCA	TCGA	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation blocking phosphorylation signal	0.5
p.T1195A	DO4197	BRCA	ICGC	VCLHVD	LIG_APCC_ABBA_1	1205:1210	Mutation blocking phosphorylation signal	0.5
p.C1279Y	TCGA-AP-A051	UCEC	TCGA	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.3056
p.C1279Y	DO42673	UCEC	ICGC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.3056
p.R1799G	DO225390	BRCA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.3056
p.A1272T	TCGA-DU-6392	LGG	TCGA	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.2778
p.A1272T	DO22237	LGG	ICGC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.2778
p.A1272T	SIDM01307	Colorectal Carcinoma	GDSC	PDTST	DEG_SPOP_SBC_1	1274:1278	Mutation rewiring degron network	0.2778
p.Q1791H	DO14830	HNSC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	1793:1798	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 62 entries

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Kaplan plot for VPS13B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VPS13B

UniProt ID: Q7Z7G8

Entrez ID: 157680

Protein name: Intermembrane lipid transfer protein VPS13B (Cohen syndrome protein 1) (Vacuolar protein sorting-associated protein 13B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VPS13B in