DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VCLHVD
Uniprot ID:
Q7Z7G8
Source protein:
Intermembrane lipid transfer protein VPS13B
Source gene:
VPS13B
Class:
LIG_APCC_ABBA_1
Location:
1205:1210
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6969
ASA_SCORE:
25.9
COIL:
0.2077
CONS_SCORE:
0.632
DSS_SCORE:
0.0453
HELIX:
0.025
FCONS_SCORE:
1.3824
RIG_SCORE:
0.9258
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R1200G
TCGA-2G-AAKL
TGCT
TCGA
VCLHVD
LIG_APCC_ABBA_1
0.1944
p.G1196E
TCGA-49-4487
LUAD
TCGA
VCLHVD
LIG_APCC_ABBA_1
0.0833
p.G1196E
DO24780
LUAD
ICGC
VCLHVD
LIG_APCC_ABBA_1
0.0833
p.T1195A
TCGA-AR-A2LN
BRCA
TCGA
VCLHVD
LIG_APCC_ABBA_1
0.5
p.T1195A
DO4197
BRCA
ICGC
VCLHVD
LIG_APCC_ABBA_1
0.5
p.R1200Q
TCGA-EO-A22R
UCEC
TCGA
VCLHVD
LIG_APCC_ABBA_1
0.1944
p.R1200Q
DO42713
UCEC
ICGC
VCLHVD
LIG_APCC_ABBA_1
0.1944
p.R1200Q
ACH-001687
Kidney Cancer
CCLE
VCLHVD
LIG_APCC_ABBA_1
0.1944
p.S1219C
TCGA-VQ-A8PM
STAD
TCGA
VCLHVD
LIG_APCC_ABBA_1
0.0833
p.S1219C
DO51772
STAD
ICGC
VCLHVD
LIG_APCC_ABBA_1
0.0833
p.S1213L
DO234469
ESAD
ICGC
VCLHVD
LIG_APCC_ABBA_1
0.25
p.C1206Y
DO233814
GACA
ICGC
VCLHVD
LIG_APCC_ABBA_1
0.5976
p.V1209F
DO229026
LICA
ICGC
VCLHVD
LIG_APCC_ABBA_1
0.5957
p.C1218F
DO229045
LICA
ICGC
VCLHVD
LIG_APCC_ABBA_1
0.1111
p.S1219F
SIDM00113
Kidney Carcinoma
GDSC
VCLHVD
LIG_APCC_ABBA_1
0.0833
p.S1219F
ACH-001208
Kidney Cancer
CCLE
VCLHVD
LIG_APCC_ABBA_1
0.0833
p.S1219F
TK10
kidney
COSMIC
VCLHVD
LIG_APCC_ABBA_1
0.0833
Drug responses associated with VPS13B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VCLHVD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z7G8
Intermembrane lipid transfer protein VPS13B
LIG_APCC_ABBA_1
1205:1210
VCLHVD
APC,CDC20,FZR1
0.6969
More...
Q9NS37
CREB/ATF bZIP transcription factor
LIG_APCC_ABBA_1
327:332
VCLHVD
APC,CDC20,FZR1
0.585
More...