DegronMD

Uniprot ID: Q9NS37

Source protein: CREB/ATF bZIP transcription factor

Source gene: CREBZF

Class: LIG_APCC_ABBA_1

Location: 327:332

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.585

ASA_SCORE: 33.1333

COIL: 0.1968

CONS_SCORE: 0.8679

DSS_SCORE: 0.2284

HELIX: 0.0175

FCONS_SCORE: 1.5617

RIG_SCORE: 0.8182

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E320K	TCGA-A5-A0G1	UCEC	TCGA	VCLHVD	LIG_APCC_ABBA_1	0.1389
p.E320K	DO42472	UCEC	ICGC	VCLHVD	LIG_APCC_ABBA_1	0.1389
p.S337A	TCGA-BP-5173	KIRC	TCGA	VCLHVD	LIG_APCC_ABBA_1	0.1944
p.S337A	DO20289	KIRC	ICGC	VCLHVD	LIG_APCC_ABBA_1	0.1944
p.S337L	TCGA-FD-A3SS	BLCA	TCGA	VCLHVD	LIG_APCC_ABBA_1	0.1944
p.S337L	DO737	BLCA	ICGC	VCLHVD	LIG_APCC_ABBA_1	0.1944
p.S323A	SIDM00845	Burkitt's Lymphoma	GDSC	VCLHVD	LIG_APCC_ABBA_1	0.2222
p.S323A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VCLHVD	LIG_APCC_ABBA_1	0.2222
p.S323A	SIDM01519	Head and Neck Carcinoma	GDSC	VCLHVD	LIG_APCC_ABBA_1	0.2222
p.S323A	ACH-000786	Lymphoma	CCLE	VCLHVD	LIG_APCC_ABBA_1	0.2222
p.S323A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VCLHVD	LIG_APCC_ABBA_1	0.2222
p.V327G	ACH-000238	Head and Neck Cancer	CCLE	VCLHVD	LIG_APCC_ABBA_1	0.7532
p.H330P	ACH-000997	Colon/Colorectal Cancer	CCLE	VCLHVD	LIG_APCC_ABBA_1	0.7694
p.H330P	ACH-001061	Colon/Colorectal Cancer	CCLE	VCLHVD	LIG_APCC_ABBA_1	0.7694
p.H330P	HCT-15	large_intestine	COSMIC	VCLHVD	LIG_APCC_ABBA_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	LIG_APCC_ABBA_1	1205:1210	VCLHVD	APC,CDC20,FZR1	0.6969	More...
Q9NS37	CREB/ATF bZIP transcription factor	LIG_APCC_ABBA_1	327:332	VCLHVD	APC,CDC20,FZR1	0.585	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons