DegronMD - Q9NS37(CREBZF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S137W	TCGA-32-4208	GBM	TCGA	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2222
p.S137W	DO11352	GBM	ICGC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2222
p.E320K	TCGA-A5-A0G1	UCEC	TCGA	VCLHVD	LIG_APCC_ABBA_1	327:332	Mutation rewiring degron network	0.1389
p.E320K	DO42472	UCEC	ICGC	VCLHVD	LIG_APCC_ABBA_1	327:332	Mutation rewiring degron network	0.1389
p.S137L	TCGA-AC-A6IV	BRCA	TCGA	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2222
p.S137L	DO44246	BRCA	ICGC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.2222
p.H119Y	TCGA-AX-A0J1	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0556
p.H119Y	DO41199	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0556
p.S337A	TCGA-BP-5173	KIRC	TCGA	VCLHVD	LIG_APCC_ABBA_1	327:332	Mutation rewiring degron network	0.1944
p.S337A	DO20289	KIRC	ICGC	VCLHVD	LIG_APCC_ABBA_1	327:332	Mutation rewiring degron network	0.1944
p.S132L	TCGA-EK-A3GN	CESC	TCGA	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7667
p.S132L	DO49968	CESC	ICGC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7667
p.D138G	TCGA-EO-A22U	UCEC	TCGA	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1944
p.D138G	DO43755	UCEC	ICGC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1944
p.S337L	TCGA-FD-A3SS	BLCA	TCGA	VCLHVD	LIG_APCC_ABBA_1	327:332	Mutation rewiring degron network	0.1944
p.S337L	DO737	BLCA	ICGC	VCLHVD	LIG_APCC_ABBA_1	327:332	Mutation rewiring degron network	0.1944
p.L130F	TCGA-QQ-A5VD	SARC	TCGA	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.587
p.L130F	DO220252	SARC	ICGC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.587
p.L8V	TCGA-XF-AAMG	BLCA	TCGA	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.5654
p.L8V	DO219049	BLCA	ICGC	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.5654
p.P6A	DO233220	GACA	ICGC	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.7503
p.H119Q	DO228974	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0556
p.L120M	DO228976	LICA	ICGC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.0833
p.S323A	SIDM00845	Burkitt's Lymphoma	GDSC	VCLHVD	LIG_APCC_ABBA_1	327:332	Mutation rewiring degron network	0.2222
p.S323A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VCLHVD	LIG_APCC_ABBA_1	327:332	Mutation rewiring degron network	0.2222
p.S323A	SIDM01519	Head and Neck Carcinoma	GDSC	VCLHVD	LIG_APCC_ABBA_1	327:332	Mutation rewiring degron network	0.2222
p.S323A	ACH-000786	Lymphoma	CCLE	VCLHVD	LIG_APCC_ABBA_1	327:332	Mutation rewiring degron network	0.2222
p.S323A	Daudi	haematopoietic and lymphoid tissue	COSMIC	VCLHVD	LIG_APCC_ABBA_1	327:332	Mutation rewiring degron network	0.2222
p.G128R	SIDM00113	Kidney Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.G128R	ACH-001208	Kidney Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.G128R	TK10	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.S14N	SIDM00565	Oral Cavity Carcinoma	GDSC	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation blocking phosphorylation signal	0.6389
p.S14N	SIDM00308	Chronic Myelogenous Leukemia	GDSC	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation blocking phosphorylation signal	0.6389
p.S14N	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation blocking phosphorylation signal	0.6389
p.S14N	ACH-000074	Leukemia	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation blocking phosphorylation signal	0.6389
p.S14N	ACH-000452	Esophageal Cancer	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation blocking phosphorylation signal	0.6389
p.S14N	ACH-001393	Breast Cancer	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation blocking phosphorylation signal	0.6389
p.S14N	ACH-001626	Head and Neck Cancer	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation blocking phosphorylation signal	0.6389
p.S14N	KU812	haematopoietic and lymphoid tissue	COSMIC	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation blocking phosphorylation signal	0.6389
p.S14N	OSC-20	upper aerodigestive tract	COSMIC	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation blocking phosphorylation signal	0.6389
p.S14N	TE-8	oesophagus	COSMIC	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation blocking phosphorylation signal	0.6389
p.S4N	SIDM00848	Ewing's Sarcoma	GDSC	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.5958
p.S4N	ACH-000052	Bone Cancer	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.5958
p.S4N	A673	bone	COSMIC	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.5958
p.G128V	SIDM01162	Kidney Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.G128V	ACH-001398	Kidney Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.G128V	SW156	kidney	COSMIC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.L124R	SIDM01145	Gastric Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1944
p.L124R	SIDM00324	Neuroblastoma	GDSC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1944
p.L124R	NCI-SNU-16	stomach	COSMIC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.1944
p.R19H	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.0556
p.R19H	ACH-000853	Lung Cancer	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.0556
p.S131F	SIDM00516	Melanoma	GDSC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation altering degron motif	0.7982
p.G134D	SIDM00537	Colorectal Carcinoma	GDSC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.G134D	ACH-001345	Colon/Colorectal Cancer	CCLE	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.G134D	GP5d	large intestine	COSMIC	PLSSS	DEG_SPOP_SBC_1	129:133	Mutation rewiring degron network	0.3056
p.R2K	SIDM01618	B-Lymphoblastic Leukemia	GDSC	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.7237
p.R2K	ACH-000942	Leukemia	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.7237
p.V327G	ACH-000238	Head and Neck Cancer	CCLE	VCLHVD	LIG_APCC_ABBA_1	327:332	Mutation altering degron motif	0.7532
p.S12W	ACH-000945	Lung Cancer	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.25
p.H330P	ACH-000997	Colon/Colorectal Cancer	CCLE	VCLHVD	LIG_APCC_ABBA_1	327:332	Mutation altering degron motif	0.7694
p.H330P	ACH-001061	Colon/Colorectal Cancer	CCLE	VCLHVD	LIG_APCC_ABBA_1	327:332	Mutation altering degron motif	0.7694
p.H330P	HCT-15	large intestine	COSMIC	VCLHVD	LIG_APCC_ABBA_1	327:332	Mutation altering degron motif	0.7694

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CREBZF

UniProt ID: Q9NS37

Entrez ID: 58487

Protein name: CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CREBZF in