DegronMD

Uniprot ID: Q9NS37

Source protein: CREB/ATF bZIP transcription factor

Source gene: CREBZF

Class: DEG_APCC_DBOX_1

Location: 1:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7709

ASA_SCORE: 102.5

COIL: 0.638

CONS_SCORE: 0.4715

DSS_SCORE: 0.832

HELIX: 0.3038

FCONS_SCORE: 1.0052

RIG_SCORE: 0.7518

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L8V	TCGA-XF-AAMG	BLCA	TCGA	MRHSLTKLL	DEG_APCC_DBOX_1	0.5654
p.L8V	DO219049	BLCA	ICGC	MRHSLTKLL	DEG_APCC_DBOX_1	0.5654
p.P6A	DO233220	GACA	ICGC	MRHSLTKLL	DEG_APCC_DBOX_1	0.7503
p.S14N	SIDM00565	Oral Cavity Carcinoma	GDSC	MRHSLTKLL	DEG_APCC_DBOX_1	0.6389
p.S14N	SIDM00308	Chronic Myelogenous Leukemia	GDSC	MRHSLTKLL	DEG_APCC_DBOX_1	0.6389
p.S14N	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	MRHSLTKLL	DEG_APCC_DBOX_1	0.6389
p.S14N	ACH-000074	Leukemia	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	0.6389
p.S14N	ACH-000452	Esophageal Cancer	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	0.6389
p.S14N	ACH-001393	Breast Cancer	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	0.6389
p.S14N	ACH-001626	Head and Neck Cancer	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	0.6389
p.S14N	KU812	haematopoietic_and_lymphoid_tissue	COSMIC	MRHSLTKLL	DEG_APCC_DBOX_1	0.6389
p.S14N	OSC-20	upper_aerodigestive_tract	COSMIC	MRHSLTKLL	DEG_APCC_DBOX_1	0.6389
p.S14N	TE-8	oesophagus	COSMIC	MRHSLTKLL	DEG_APCC_DBOX_1	0.6389
p.S4N	SIDM00848	Ewing's Sarcoma	GDSC	MRHSLTKLL	DEG_APCC_DBOX_1	0.5958
p.S4N	ACH-000052	Bone Cancer	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	0.5958
p.S4N	A673	bone	COSMIC	MRHSLTKLL	DEG_APCC_DBOX_1	0.5958
p.R19H	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	MRHSLTKLL	DEG_APCC_DBOX_1	0.0556
p.R19H	ACH-000853	Lung Cancer	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	0.0556
p.R2K	SIDM01618	B-Lymphoblastic Leukemia	GDSC	MRHSLTKLL	DEG_APCC_DBOX_1	0.7237
p.R2K	ACH-000942	Leukemia	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	0.7237
p.S12W	ACH-000945	Lung Cancer	CCLE	MRHSLTKLL	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NS37	CREB/ATF bZIP transcription factor	DEG_APCC_DBOX_1	1:9	MRHSLTKLL	APC,CDC20,FZR1	0.7709	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons