DegronMD

Uniprot ID: Q7Z7G8

Source protein: Intermembrane lipid transfer protein VPS13B

Source gene: VPS13B

Class: DEG_SCF_TRCP1_1

Location: 1793:1798

E3 ligase: BTRC

DEGRON score: 0.9953

ASA_SCORE: 51.4833

COIL: 0.7208

CONS_SCORE: 0.5022

DSS_SCORE: 0.458

HELIX: 0.0505

FCONS_SCORE: 1.2491

RIG_SCORE: 0.6299

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1795V	TCGA-06-1802	GBM	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.7532
p.G1795V	DO12100	GBM	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.7532
p.I1808R	TCGA-AA-3956	COAD	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.0556
p.G1797C	TCGA-CK-5913	COAD	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.6489
p.G1797C	DO8826	COAD	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.6489
p.R1804T	TCGA-DS-A0VM	CESC	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.1667
p.V1801F	TCGA-YD-A9TA	SKCM	TCGA	DSGIGS	DEG_SCF_TRCP1_1	0.25
p.R1799G	DO225390	BRCA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.3056
p.I1783R	DO9700	COAD	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.0556
p.Q1791H	DO14830	HNSC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.2778
p.E1784D	DO228974	LICA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.0833
p.V1804L	DO229029	LICA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.1667
p.S1800I	DO229036	LICA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.7222
p.E1784Q	DO45475	LUSC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	0.0833
p.R1787C	SIDM02075	Colorectal Carcinoma	GDSC	DSGIGS	DEG_SCF_TRCP1_1	0.1667
p.R1787C	SIDM00221	Melanoma	GDSC	DSGIGS	DEG_SCF_TRCP1_1	0.1667
p.R1787C	SIDM01588	Endometrial Carcinoma	GDSC	DSGIGS	DEG_SCF_TRCP1_1	0.1667
p.R1787C	ACH-000855	Esophageal Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	0.1667
p.R1787C	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	0.1667
p.R1787C	ACH-002388	Skin Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	0.1667
p.D1793H	ACH-000831	Endometrial/Uterine Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	0.7688
p.T1784N	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5D1E8	Endoribonuclease ZC3H12A	DEG_SCF_TRCP1_1	437:442	DSGIGS	BTRC	0.9148	More...
Q7Z7G8	Intermembrane lipid transfer protein VPS13B	DEG_SCF_TRCP1_1	1793:1798	DSGIGS	BTRC	0.9953	More...
Q8NG31	Kinetochore scaffold 1	DEG_SCF_TRCP1_1	1719:1724	DSGIGS	BTRC	0.9854	More...
Q5VUJ6	Leucine-rich repeat and calponin homology domain-containing protein 2	DEG_SCF_TRCP1_1	346:351	DSGIGS	BTRC	0.9491	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons