DegronMD - Q5VUJ6(LRCH2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N353Y	TCGA-58-A46M	LUSC	TCGA	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation rewiring degron network	0.2778
p.N353Y	DO45485	LUSC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation rewiring degron network	0.2778
p.N342K	TCGA-AG-A015	READ	TCGA	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation rewiring degron network	0.2222
p.K341N	TCGA-B5-A11N	UCEC	TCGA	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation substituting flanking lysine	0.3056
p.K341N	DO41458	UCEC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation substituting flanking lysine	0.3056
p.Y338C	TCGA-EO-A22R	UCEC	TCGA	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation rewiring degron network	0.1111
p.Y338C	DO42713	UCEC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation rewiring degron network	0.1111
p.N353T	DO227849	COCA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation rewiring degron network	0.2778
p.G344C	DO23276	LINC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation rewiring degron network	0.2778
p.G344V	DO23276	LINC	ICGC	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation rewiring degron network	0.2778
p.D352G	DO229253	THCA	ICGC	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation rewiring degron network	0.3056
p.E355V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation rewiring degron network	0.2222
p.E355V	ACH-000924	Lung Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation rewiring degron network	0.2222
p.E355V	NCI-H2172	lung	COSMIC	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation rewiring degron network	0.2222
p.D346E	SIDM01056	Breast Carcinoma	GDSC	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation altering degron motif	0.6758
p.D346E	ACH-000330	Breast Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation altering degron motif	0.6758
p.D346E	EFM-19	breast	COSMIC	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation altering degron motif	0.6758
p.G350E	SIDM01133	Other Solid Cancers	GDSC	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation altering degron motif	0.6087
p.G350E	ACH-002177	Lung Cancer	CCLE	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation altering degron motif	0.6087
p.G350E	NCI-H835	lung	COSMIC	DSGIGS	DEG_SCF_TRCP1_1	346:351	Mutation altering degron motif	0.6087

Kaplan plot for LRCH2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRCH2

UniProt ID: Q5VUJ6

Entrez ID: 57631

Protein name: Leucine-rich repeat and calponin homology domain-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRCH2 in