DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
KTIVFSE
Uniprot ID:
Q8NG31
Source protein:
Kinetochore scaffold 1
Source gene:
KNL1
Class:
LIG_APCC_ABBAyCdc20_2
Location:
886:892
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.834
ASA_SCORE:
77.6286
COIL:
0.5997
CONS_SCORE:
0.4744
DSS_SCORE:
0.4127
HELIX:
0.0303
FCONS_SCORE:
1.1168
RIG_SCORE:
0.8279
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D897E
SIDM00863
Burkitt's Lymphoma
GDSC
KTIVFSE
LIG_APCC_ABBAyCdc20_2
0.1944
p.S902F
KYSE-220
oesophagus
COSMIC
KTIVFSE
LIG_APCC_ABBAyCdc20_2
0.1667
Drug responses associated with KNL1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KTIVFSE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NG31
Kinetochore scaffold 1
LIG_APCC_ABBAyCdc20_2
886:892
KTIVFSE
APC,CDC20,FZR1
0.834
More...
Q8NG31
Kinetochore scaffold 1
LIG_APCC_ABBAyCdc20_2
1100:1106
KTIVFSE
APC,CDC20,FZR1
0.9782
More...