DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
KTIVFSE
Uniprot ID:
Q8NG31
Source protein:
Kinetochore scaffold 1
Source gene:
KNL1
Class:
LIG_APCC_ABBAyCdc20_2
Location:
1100:1106
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9782
ASA_SCORE:
78.5
COIL:
0.6684
CONS_SCORE:
0.4199
DSS_SCORE:
0.4151
HELIX:
0.0476
FCONS_SCORE:
1.0877
RIG_SCORE:
0.7704
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with KNL1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KTIVFSE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NG31
Kinetochore scaffold 1
LIG_APCC_ABBAyCdc20_2
886:892
KTIVFSE
APC,CDC20,FZR1
0.834
More...
Q8NG31
Kinetochore scaffold 1
LIG_APCC_ABBAyCdc20_2
1100:1106
KTIVFSE
APC,CDC20,FZR1
0.9782
More...