DegronMD - Q8TAQ2(SMARCC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M1153V	TCGA-2H-A9GK	ESCA	TCGA	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.3056
p.T552I	TCGA-AJ-A8CT	UCEC	TCGA	PKTPQQT	DEG_SCF_FBW7_1	546:552	Mutation altering degron motif	0.7078
p.T552I	DO52399	UCEC	ICGC	PKTPQQT	DEG_SCF_FBW7_1	546:552	Mutation altering degron motif	0.7078
p.V542L	TCGA-C8-A12K	BRCA	TCGA	PKTPQQT	DEG_SCF_FBW7_1	546:552	Mutation rewiring degron network	0.2222
p.V542L	DO1258	BRCA	ICGC	PKTPQQT	DEG_SCF_FBW7_1	546:552	Mutation rewiring degron network	0.2222
p.D536N	TCGA-C8-A26Y	BRCA	TCGA	PKTPQQT	DEG_SCF_FBW7_1	546:552	Mutation rewiring degron network	0.0556
p.D536N	DO1273	BRCA	ICGC	PKTPQQT	DEG_SCF_FBW7_1	546:552	Mutation rewiring degron network	0.0556
p.S737R	TCGA-CM-6163	COAD	TCGA	AGTTS	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.2222
p.S737R	DO9194	COAD	ICGC	AGTTS	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.2222
p.S1138F	TCGA-IB-7651	PAAD	TCGA	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.0556
p.S553F	TCGA-K4-A5RH	BLCA	TCGA	PKTPQQT	DEG_SCF_FBW7_1	546:552	Mutation blocking phosphorylation signal	0.75
p.S553F	DO219028	BLCA	ICGC	PKTPQQT	DEG_SCF_FBW7_1	546:552	Mutation blocking phosphorylation signal	0.75
p.S754C	DO52438	COCA	ICGC	AGTTS	DEG_SPOP_SBC_1	741:745	Mutation blocking phosphorylation signal	0.5278
p.E753Q	DO222734	ESCA	ICGC	AGTTS	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1111
p.G755R	DO228947	LICA	ICGC	AGTTS	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.0556
p.P731T	DO229045	LICA	ICGC	AGTTS	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.0556
p.A1139V	DO50881	LICA	ICGC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.0833
p.L735Q	DO23298	LINC	ICGC	AGTTS	DEG_SPOP_SBC_1	741:745	Mutation rewiring degron network	0.1667
p.P562A	DO51955	PRAD	ICGC	PKTPQQT	DEG_SCF_FBW7_1	546:552	Mutation rewiring degron network	0.0556
p.P1142T	DO37595	SKCM	ICGC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.1667
p.P1140L	DO40996	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.1111
p.H1148Y	DO41784	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation altering degron motif	0.7229
p.L1161I	SIDM00845	Burkitt's Lymphoma	GDSC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.0833
p.L1161I	SIDM00461	Acute Myeloid Leukemia	GDSC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.0833
p.L1161I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.0833
p.L1161I	SIDM01519	Head and Neck Carcinoma	GDSC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.0833
p.L1161I	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.0833
p.L1161I	DND-41	haematopoietic and lymphoid tissue	COSMIC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.0833
p.L1161I	Daudi	haematopoietic and lymphoid tissue	COSMIC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.0833
p.A1143P	SIDM00845	Burkitt's Lymphoma	GDSC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.1944
p.A1143P	Daudi	haematopoietic and lymphoid tissue	COSMIC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.1944
p.A1143P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.1944
p.D555Y	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	PKTPQQT	DEG_SCF_FBW7_1	546:552	Mutation blocking phosphorylation signal	0.6944
p.D555Y	NCI-H2347	lung	COSMIC	PKTPQQT	DEG_SCF_FBW7_1	546:552	Mutation blocking phosphorylation signal	0.6944
p.T1152A	ACH-000988	Endometrial/Uterine Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation altering degron motif	0.7139
p.T1152A	MFE-319	endometrium	COSMIC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation altering degron motif	0.7139
p.S1156F	ACH-002309	Sarcoma	CCLE	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.2222
p.S1156F	SW684	soft tissue	COSMIC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.2222
p.P1161L	Hep_3B2_1-7	NS	COSMIC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.0833
p.P1161L	MFE-296	endometrium	COSMIC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.0833
p.N1141T	CAL-33	upper aerodigestive tract	COSMIC	PATTT	DEG_SPOP_SBC_1	1148:1152	Mutation rewiring degron network	0.1389

Kaplan plot for SMARCC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMARCC2

UniProt ID: Q8TAQ2

Entrez ID: 6601

Protein name: SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMARCC2 in