DegronMD

Uniprot ID: Q8TAQ2

Source protein: SWI/SNF complex subunit SMARCC2

Source gene: SMARCC2

Class: DEG_SPOP_SBC_1

Location: 1148:1152

E3 ligase: SPOP

DEGRON score: 0.9655

ASA_SCORE: 81.52

COIL: 0.9246

CONS_SCORE: 0.1835

DSS_SCORE: 0.5435

HELIX: 0.0338

FCONS_SCORE: 0.9897

RIG_SCORE: 0.6746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1153V	TCGA-2H-A9GK	ESCA	TCGA	PATTT	DEG_SPOP_SBC_1	0.3056
p.S1138F	TCGA-IB-7651	PAAD	TCGA	PATTT	DEG_SPOP_SBC_1	0.0556
p.A1139V	DO50881	LICA	ICGC	PATTT	DEG_SPOP_SBC_1	0.0833
p.P1142T	DO37595	SKCM	ICGC	PATTT	DEG_SPOP_SBC_1	0.1667
p.P1140L	DO40996	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	0.1111
p.H1148Y	DO41784	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	0.7229
p.L1161I	SIDM00845	Burkitt's Lymphoma	GDSC	PATTT	DEG_SPOP_SBC_1	0.0833
p.L1161I	SIDM00461	Acute Myeloid Leukemia	GDSC	PATTT	DEG_SPOP_SBC_1	0.0833
p.L1161I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PATTT	DEG_SPOP_SBC_1	0.0833
p.L1161I	SIDM01519	Head and Neck Carcinoma	GDSC	PATTT	DEG_SPOP_SBC_1	0.0833
p.L1161I	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PATTT	DEG_SPOP_SBC_1	0.0833
p.L1161I	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PATTT	DEG_SPOP_SBC_1	0.0833
p.L1161I	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PATTT	DEG_SPOP_SBC_1	0.0833
p.A1143P	SIDM00845	Burkitt's Lymphoma	GDSC	PATTT	DEG_SPOP_SBC_1	0.1944
p.A1143P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PATTT	DEG_SPOP_SBC_1	0.1944
p.A1143P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PATTT	DEG_SPOP_SBC_1	0.1944
p.T1152A	ACH-000988	Endometrial/Uterine Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	0.7139
p.T1152A	MFE-319	endometrium	COSMIC	PATTT	DEG_SPOP_SBC_1	0.7139
p.S1156F	ACH-002309	Sarcoma	CCLE	PATTT	DEG_SPOP_SBC_1	0.2222
p.S1156F	SW684	soft_tissue	COSMIC	PATTT	DEG_SPOP_SBC_1	0.2222
p.P1161L	Hep_3B2_1-7	NS	COSMIC	PATTT	DEG_SPOP_SBC_1	0.0833
p.P1161L	MFE-296	endometrium	COSMIC	PATTT	DEG_SPOP_SBC_1	0.0833
p.N1141T	CAL-33	upper_aerodigestive_tract	COSMIC	PATTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	311:315	PATTT	SPOP	0.8955	More...
P31645	Sodium-dependent serotonin transporter	DEG_SPOP_SBC_1	64:68	PATTT	SPOP	0.7561	More...
P51587	Breast cancer type 2 susceptibility protein	DEG_SPOP_SBC_1	564:568	PATTT	SPOP	0.9146	More...
Q03001	Dystonin	DEG_SPOP_SBC_1	7436:7440	PATTT	SPOP	0.9065	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	498:502	PATTT	SPOP	0.9968	More...
Q6EMK4	Vasorin	DEG_SPOP_SBC_1	350:354	PATTT	SPOP	0.9976	More...
Q6ISU1	Pre T-cell antigen receptor alpha	DEG_SPOP_SBC_1	182:186	PATTT	SPOP	0.9264	More...
Q765P7	Protein MTSS 2	DEG_SPOP_SBC_1	313:317	PATTT	SPOP	0.6279	More...
Q86UK7	E3 ubiquitin-protein ligase ZNF598	DEG_SPOP_SBC_1	729:733	PATTT	SPOP	0.9959	More...
Q8N3V7	Synaptopodin	DEG_SPOP_SBC_1	407:411	PATTT	SPOP	0.998	More...
Q8N9I0	Synaptotagmin-2	DEG_SPOP_SBC_1	15:19	PATTT	SPOP	0.7121	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1537:1541	PATTT	SPOP	0.9939	More...
Q8TAQ2	SWI/SNF complex subunit SMARCC2	DEG_SPOP_SBC_1	1148:1152	PATTT	SPOP	0.9655	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7725:7729	PATTT	SPOP	0.9548	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	62:66	PATTT	SPOP	0.9768	More...
Q9H3S7	Tyrosine-protein phosphatase non-receptor type 23	DEG_SPOP_SBC_1	879:883	PATTT	SPOP	0.9977	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	695:699	PATTT	SPOP	0.9941	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	1042:1046	PATTT	SPOP	0.8197	More...
Q9H8Y8	Golgi reassembly-stacking protein 2	DEG_SPOP_SBC_1	397:401	PATTT	SPOP	0.999	More...
Q9NYI0	PH and SEC7 domain-containing protein 3	DEG_SPOP_SBC_1	921:925	PATTT	SPOP	0.9983	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	428:432	PATTT	SPOP	0.947	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_SPOP_SBC_1	78:82	PATTT	SPOP	0.9893	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2539:2543	PATTT	SPOP	0.77	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	1824:1828	PATTT	SPOP	0.9363	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	220:224	PATTT	SPOP	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATTT

Degron related mutations and impact score

Drug responses associated with SMARCC2 mutations

All proteins holding degron of PATTT