DegronMD

Uniprot ID: Q9H8Y8

Source protein: Golgi reassembly-stacking protein 2

Source gene: GORASP2

Class: DEG_SPOP_SBC_1

Location: 397:401

E3 ligase: SPOP

DEGRON score: 0.999

ASA_SCORE: 77.46

COIL: 0.906

CONS_SCORE: 0.3846

DSS_SCORE: 0.635

HELIX: 0.029

FCONS_SCORE: 1.1378

RIG_SCORE: 0.6406

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S409L	TCGA-17-Z061	LUAD	TCGA	PATTT	DEG_SPOP_SBC_1	0.5556
p.T390S	TCGA-46-3765	LUSC	TCGA	PATTT	DEG_SPOP_SBC_1	0.1389
p.T390S	DO26959	LUSC	ICGC	PATTT	DEG_SPOP_SBC_1	0.1389
p.A393T	TCGA-AM-5821	COAD	TCGA	PATTT	DEG_SPOP_SBC_1	0.2222
p.A393T	TCGA-AZ-6598	COAD	TCGA	PATTT	DEG_SPOP_SBC_1	0.2222
p.A393T	TCGA-BR-8081	STAD	TCGA	PATTT	DEG_SPOP_SBC_1	0.2222
p.A393T	DO10276	COAD	ICGC	PATTT	DEG_SPOP_SBC_1	0.2222
p.A393T	DO8240	COAD	ICGC	PATTT	DEG_SPOP_SBC_1	0.2222
p.A393T	DO38795	STAD	ICGC	PATTT	DEG_SPOP_SBC_1	0.2222
p.A406T	TCGA-DU-6392	LGG	TCGA	PATTT	DEG_SPOP_SBC_1	0.1944
p.A406T	TCGA-G4-6628	COAD	TCGA	PATTT	DEG_SPOP_SBC_1	0.1944
p.A406T	DO10132	COAD	ICGC	PATTT	DEG_SPOP_SBC_1	0.1944
p.A406T	DO222492	COCA	ICGC	PATTT	DEG_SPOP_SBC_1	0.1944
p.A406T	DO233156	GACA	ICGC	PATTT	DEG_SPOP_SBC_1	0.1944
p.A406T	DO22237	LGG	ICGC	PATTT	DEG_SPOP_SBC_1	0.1944
p.P389S	DO233156	GACA	ICGC	PATTT	DEG_SPOP_SBC_1	0.1111
p.A398S	DO229009	LICA	ICGC	PATTT	DEG_SPOP_SBC_1	0.6477
p.P388S	ACH-000960	Leukemia	CCLE	PATTT	DEG_SPOP_SBC_1	0.0833
p.T390P	SK-LMS-1	soft_tissue	COSMIC	PATTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	311:315	PATTT	SPOP	0.8955	More...
P31645	Sodium-dependent serotonin transporter	DEG_SPOP_SBC_1	64:68	PATTT	SPOP	0.7561	More...
P51587	Breast cancer type 2 susceptibility protein	DEG_SPOP_SBC_1	564:568	PATTT	SPOP	0.9146	More...
Q03001	Dystonin	DEG_SPOP_SBC_1	7436:7440	PATTT	SPOP	0.9065	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	498:502	PATTT	SPOP	0.9968	More...
Q6EMK4	Vasorin	DEG_SPOP_SBC_1	350:354	PATTT	SPOP	0.9976	More...
Q6ISU1	Pre T-cell antigen receptor alpha	DEG_SPOP_SBC_1	182:186	PATTT	SPOP	0.9264	More...
Q765P7	Protein MTSS 2	DEG_SPOP_SBC_1	313:317	PATTT	SPOP	0.6279	More...
Q86UK7	E3 ubiquitin-protein ligase ZNF598	DEG_SPOP_SBC_1	729:733	PATTT	SPOP	0.9959	More...
Q8N3V7	Synaptopodin	DEG_SPOP_SBC_1	407:411	PATTT	SPOP	0.998	More...
Q8N9I0	Synaptotagmin-2	DEG_SPOP_SBC_1	15:19	PATTT	SPOP	0.7121	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1537:1541	PATTT	SPOP	0.9939	More...
Q8TAQ2	SWI/SNF complex subunit SMARCC2	DEG_SPOP_SBC_1	1148:1152	PATTT	SPOP	0.9655	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7725:7729	PATTT	SPOP	0.9548	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	62:66	PATTT	SPOP	0.9768	More...
Q9H3S7	Tyrosine-protein phosphatase non-receptor type 23	DEG_SPOP_SBC_1	879:883	PATTT	SPOP	0.9977	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	695:699	PATTT	SPOP	0.9941	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	1042:1046	PATTT	SPOP	0.8197	More...
Q9H8Y8	Golgi reassembly-stacking protein 2	DEG_SPOP_SBC_1	397:401	PATTT	SPOP	0.999	More...
Q9NYI0	PH and SEC7 domain-containing protein 3	DEG_SPOP_SBC_1	921:925	PATTT	SPOP	0.9983	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	428:432	PATTT	SPOP	0.947	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_SPOP_SBC_1	78:82	PATTT	SPOP	0.9893	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2539:2543	PATTT	SPOP	0.77	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	1824:1828	PATTT	SPOP	0.9363	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	220:224	PATTT	SPOP	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATTT

Degron related mutations and impact score

Drug responses associated with GORASP2 mutations

All proteins holding degron of PATTT