DegronMD

Uniprot ID: P51587

Source protein: Breast cancer type 2 susceptibility protein

Source gene: BRCA2

Class: DEG_SPOP_SBC_1

Location: 564:568

E3 ligase: SPOP

DEGRON score: 0.9146

ASA_SCORE: 76.42

COIL: 0.7232

CONS_SCORE: 0.3438

DSS_SCORE: 0.3492

HELIX: 0.2018

FCONS_SCORE: 1.0611

RIG_SCORE: 0.7817

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C554F	TCGA-73-4662	LUAD	TCGA	PATTT	DEG_SPOP_SBC_1	0.0556
p.C554F	DO229022	LICA	ICGC	PATTT	DEG_SPOP_SBC_1	0.0556
p.C554F	DO24790	LUAD	ICGC	PATTT	DEG_SPOP_SBC_1	0.0556
p.A577S	TCGA-97-7554	LUAD	TCGA	PATTT	DEG_SPOP_SBC_1	0.0833
p.A577S	DO23592	LUAD	ICGC	PATTT	DEG_SPOP_SBC_1	0.0833
p.K575N	TCGA-A5-A2K5	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	0.25
p.K575N	DO41379	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	0.25
p.Q569H	TCGA-AP-A0LM	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	0.3056
p.Q569H	DO43306	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	0.3056
p.S571F	TCGA-AP-A0LM	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	0.25
p.S571F	DO43306	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	0.25
p.L557V	TCGA-AX-A05Z	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	0.1389
p.L557V	DO40884	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	0.1389
p.P555L	TCGA-EE-A29C	SKCM	TCGA	PATTT	DEG_SPOP_SBC_1	0.0833
p.P555L	DO222727	MELA	ICGC	PATTT	DEG_SPOP_SBC_1	0.0833
p.P555L	DO38028	SKCM	ICGC	PATTT	DEG_SPOP_SBC_1	0.0833
p.N556S	TCGA-P4-AAVM	KIRP	TCGA	PATTT	DEG_SPOP_SBC_1	0.1111
p.N556S	DO219695	KIRP	ICGC	PATTT	DEG_SPOP_SBC_1	0.1111
p.S562N	DO230342	COCA	ICGC	PATTT	DEG_SPOP_SBC_1	0.2778
p.S562N	ACH-000578	Lung Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	0.2778
p.G578D	SIDM00140	Melanoma	GDSC	PATTT	DEG_SPOP_SBC_1	0.0556
p.G578D	ACH-000968	Skin Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	0.0556
p.G578D	COLO-792	skin	COSMIC	PATTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	311:315	PATTT	SPOP	0.8955	More...
P31645	Sodium-dependent serotonin transporter	DEG_SPOP_SBC_1	64:68	PATTT	SPOP	0.7561	More...
P51587	Breast cancer type 2 susceptibility protein	DEG_SPOP_SBC_1	564:568	PATTT	SPOP	0.9146	More...
Q03001	Dystonin	DEG_SPOP_SBC_1	7436:7440	PATTT	SPOP	0.9065	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	498:502	PATTT	SPOP	0.9968	More...
Q6EMK4	Vasorin	DEG_SPOP_SBC_1	350:354	PATTT	SPOP	0.9976	More...
Q6ISU1	Pre T-cell antigen receptor alpha	DEG_SPOP_SBC_1	182:186	PATTT	SPOP	0.9264	More...
Q765P7	Protein MTSS 2	DEG_SPOP_SBC_1	313:317	PATTT	SPOP	0.6279	More...
Q86UK7	E3 ubiquitin-protein ligase ZNF598	DEG_SPOP_SBC_1	729:733	PATTT	SPOP	0.9959	More...
Q8N3V7	Synaptopodin	DEG_SPOP_SBC_1	407:411	PATTT	SPOP	0.998	More...
Q8N9I0	Synaptotagmin-2	DEG_SPOP_SBC_1	15:19	PATTT	SPOP	0.7121	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1537:1541	PATTT	SPOP	0.9939	More...
Q8TAQ2	SWI/SNF complex subunit SMARCC2	DEG_SPOP_SBC_1	1148:1152	PATTT	SPOP	0.9655	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7725:7729	PATTT	SPOP	0.9548	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	62:66	PATTT	SPOP	0.9768	More...
Q9H3S7	Tyrosine-protein phosphatase non-receptor type 23	DEG_SPOP_SBC_1	879:883	PATTT	SPOP	0.9977	More...
Q9H422	Homeodomain-interacting protein kinase 3	DEG_SPOP_SBC_1	695:699	PATTT	SPOP	0.9941	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	1042:1046	PATTT	SPOP	0.8197	More...
Q9H8Y8	Golgi reassembly-stacking protein 2	DEG_SPOP_SBC_1	397:401	PATTT	SPOP	0.999	More...
Q9NYI0	PH and SEC7 domain-containing protein 3	DEG_SPOP_SBC_1	921:925	PATTT	SPOP	0.9983	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	428:432	PATTT	SPOP	0.947	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_SPOP_SBC_1	78:82	PATTT	SPOP	0.9893	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	2539:2543	PATTT	SPOP	0.77	More...
Q9Y6J0	Calcineurin-binding protein cabin-1	DEG_SPOP_SBC_1	1824:1828	PATTT	SPOP	0.9363	More...
Q96KR1	Zinc finger RNA-binding protein	DEG_SPOP_SBC_1	220:224	PATTT	SPOP	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATTT

Degron related mutations and impact score

Drug responses associated with BRCA2 mutations

All proteins holding degron of PATTT