DegronMD - Q9H8Y8(GORASP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S409L	TCGA-17-Z061	LUAD	TCGA	PATTT	DEG_SPOP_SBC_1	397:401	Mutation blocking phosphorylation signal	0.5556
p.P366R	TCGA-29-1695	OV	TCGA	PESSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1667
p.P366R	DO29910	OV	ICGC	PESSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1667
p.T390S	TCGA-46-3765	LUSC	TCGA	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1389
p.T390S	DO26959	LUSC	ICGC	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1389
p.T278I	TCGA-53-7624	LUAD	TCGA	SSVLSTGVPTV	DEG_COP1_1	269:279	Mutation altering degron motif	0.7078
p.T278I	DO25058	LUAD	ICGC	SSVLSTGVPTV	DEG_COP1_1	269:279	Mutation altering degron motif	0.7078
p.A393T	TCGA-AM-5821	COAD	TCGA	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2222
p.A393T	TCGA-AZ-6598	COAD	TCGA	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2222
p.A393T	TCGA-BR-8081	STAD	TCGA	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2222
p.A393T	DO10276	COAD	ICGC	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2222
p.A393T	DO8240	COAD	ICGC	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2222
p.A393T	DO38795	STAD	ICGC	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.2222
p.P280L	TCGA-AP-A0LM	UCEC	TCGA	SSVLSTGVPTV	DEG_COP1_1	269:279	Mutation rewiring degron network	0.3056
p.P280L	DO43306	UCEC	ICGC	SSVLSTGVPTV	DEG_COP1_1	269:279	Mutation rewiring degron network	0.3056
p.S260Y	TCGA-B5-A0JY	UCEC	TCGA	SSVLSTGVPTV	DEG_COP1_1	269:279	Mutation rewiring degron network	0.0833
p.S260Y	DO43041	UCEC	ICGC	SSVLSTGVPTV	DEG_COP1_1	269:279	Mutation rewiring degron network	0.0833
p.N287H	TCGA-BG-A3PP	UCEC	TCGA	SSVLSTGVPTV	DEG_COP1_1	269:279	Mutation rewiring degron network	0.1111
p.N287H	DO48186	UCEC	ICGC	SSVLSTGVPTV	DEG_COP1_1	269:279	Mutation rewiring degron network	0.1111
p.G381E	TCGA-DF-A2KU	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.G381E	DO223286	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.1944
p.A406T	TCGA-DU-6392	LGG	TCGA	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1944
p.A406T	TCGA-G4-6628	COAD	TCGA	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1944
p.A406T	DO10132	COAD	ICGC	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1944
p.A406T	DO222492	COCA	ICGC	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1944
p.A406T	DO233156	GACA	ICGC	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1944
p.A406T	DO22237	LGG	ICGC	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1944
p.S362F	TCGA-GN-A266	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.0556
p.S362F	DO37432	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.0556
p.P369A	TCGA-ZP-A9CV	LIHC	TCGA	PESSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.25
p.P369A	DO52328	LIHC	ICGC	PESSS	DEG_SPOP_SBC_1	372:376	Mutation rewiring degron network	0.25
p.P389S	DO233156	GACA	ICGC	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1111
p.A398S	DO229009	LICA	ICGC	PATTT	DEG_SPOP_SBC_1	397:401	Mutation altering degron motif	0.6477
p.P388S	ACH-000960	Leukemia	CCLE	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.0833
p.T390P	SK-LMS-1	soft tissue	COSMIC	PATTT	DEG_SPOP_SBC_1	397:401	Mutation rewiring degron network	0.1389

Kaplan plot for GORASP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GORASP2

UniProt ID: Q9H8Y8

Entrez ID: 26003

Protein name: Golgi reassembly-stacking protein 2 (GRS2) (Golgi phosphoprotein 6) (GOLPH6) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) (p59)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GORASP2 in