DegronMD

Uniprot ID: Q9H8Y8

Source protein: Golgi reassembly-stacking protein 2

Source gene: GORASP2

Class: DEG_COP1_1

Location: 269:279

E3 ligase: COP1

DEGRON score: 0.9756

ASA_SCORE: 76.2636

COIL: 0.9285

CONS_SCORE: 0.3288

DSS_SCORE: 0.402

HELIX: 0.0196

FCONS_SCORE: 0.9307

RIG_SCORE: 0.6996

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T278I	TCGA-53-7624	LUAD	TCGA	SSVLSTGVPTV	DEG_COP1_1	0.7078
p.T278I	DO25058	LUAD	ICGC	SSVLSTGVPTV	DEG_COP1_1	0.7078
p.P280L	TCGA-AP-A0LM	UCEC	TCGA	SSVLSTGVPTV	DEG_COP1_1	0.3056
p.P280L	DO43306	UCEC	ICGC	SSVLSTGVPTV	DEG_COP1_1	0.3056
p.S260Y	TCGA-B5-A0JY	UCEC	TCGA	SSVLSTGVPTV	DEG_COP1_1	0.0833
p.S260Y	DO43041	UCEC	ICGC	SSVLSTGVPTV	DEG_COP1_1	0.0833
p.N287H	TCGA-BG-A3PP	UCEC	TCGA	SSVLSTGVPTV	DEG_COP1_1	0.1111
p.N287H	DO48186	UCEC	ICGC	SSVLSTGVPTV	DEG_COP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H8Y8	Golgi reassembly-stacking protein 2	DEG_COP1_1	269:279	SSVLSTGVPTV	COP1	0.9756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons