DegronMD - Q8N3V7(SYNPO)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A572S	TCGA-17-Z031	LUAD	TCGA	PPSY	ITCH	581:584	Mutation rewiring degron network	0.0833
p.P801S	TCGA-A5-A0GH	UCEC	TCGA	LRPSLFVLS	DEG_APCC_DBOX_1	811:819	Mutation rewiring degron network	0.0556
p.P801S	DO43634	UCEC	ICGC	LRPSLFVLS	DEG_APCC_DBOX_1	811:819	Mutation rewiring degron network	0.0556
p.P770T	TCGA-A6-6781	COAD	TCGA	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation rewiring degron network	0.0556
p.P770T	DO8447	COAD	ICGC	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation rewiring degron network	0.0556
p.P573H	TCGA-AD-6964	COAD	TCGA	PPSY	ITCH	581:584	Mutation rewiring degron network	0.1111
p.K403N	TCGA-AP-A059	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	407:411	Mutation substituting flanking lysine	0.3333
p.R579M	TCGA-AU-6004	COAD	TCGA	PPSY	ITCH	581:584	Mutation rewiring degron network	0.2778
p.R579M	DO7780	COAD	ICGC	PPSY	ITCH	581:584	Mutation rewiring degron network	0.2778
p.S580F	TCGA-AX-A2HC	UCEC	TCGA	PPSY	ITCH	581:584	Mutation blocking phosphorylation signal	0.75
p.R169C	TCGA-AX-A2HD	UCEC	TCGA	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.25
p.R395K	TCGA-BH-A2L8	BRCA	TCGA	VSTPATT	DEG_SCF_FBW7_1	404:410	Mutation rewiring degron network	0.0833
p.R395K	DO44242	BRCA	ICGC	VSTPATT	DEG_SCF_FBW7_1	404:410	Mutation rewiring degron network	0.0833
p.R812C	TCGA-BR-4257	STAD	TCGA	LRPSLFVLS	DEG_APCC_DBOX_1	811:819	Mutation altering degron motif	0.8301
p.R812C	DO222817	BTCA	ICGC	LRPSLFVLS	DEG_APCC_DBOX_1	811:819	Mutation altering degron motif	0.8301
p.R812C	DO38683	STAD	ICGC	LRPSLFVLS	DEG_APCC_DBOX_1	811:819	Mutation altering degron motif	0.8301
p.R778Q	TCGA-BS-A0UV	UCEC	TCGA	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation rewiring degron network	0.2778
p.R778Q	DO42793	UCEC	ICGC	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation rewiring degron network	0.2778
p.S356C	TCGA-DS-A0VN	CESC	TCGA	NPPATVVPQ	DEG_SIAH_1	343:351	Mutation rewiring degron network	0.1944
p.A781S	TCGA-E9-A295	BRCA	TCGA	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation altering degron motif	0.6477
p.A781S	DO3703	BRCA	ICGC	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation altering degron motif	0.6477
p.A781S	DO232761	PBCA	ICGC	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation altering degron motif	0.6477
p.T783P	TCGA-EA-A3HT	CESC	TCGA	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation altering degron motif	0.8142
p.T161P	TCGA-EO-A22R	UCEC	TCGA	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation altering degron motif	0.5919
p.T161P	DO42713	UCEC	ICGC	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation altering degron motif	0.5919
p.P807S	TCGA-EO-A22R	UCEC	TCGA	LRPSLFVLS	DEG_APCC_DBOX_1	811:819	Mutation rewiring degron network	0.2222
p.P807S	DO42713	UCEC	ICGC	LRPSLFVLS	DEG_APCC_DBOX_1	811:819	Mutation rewiring degron network	0.2222
p.A151V	TCGA-G4-6304	COAD	TCGA	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.0833
p.A151V	DO10639	COAD	ICGC	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.0833
p.I821L	TCGA-GV-A3QI	BLCA	TCGA	LRPSLFVLS	DEG_APCC_DBOX_1	811:819	Mutation rewiring degron network	0.2778
p.R782Q	TCGA-HT-8564	LGG	TCGA	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation altering degron motif	0.6218
p.R782Q	DO44623	LGG	ICGC	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation altering degron motif	0.6218
p.S415F	TCGA-RP-A694	SKCM	TCGA	VSTPATT	DEG_SCF_FBW7_1	404:410	Mutation rewiring degron network	0.1944
p.S415F	TCGA-RP-A694	SKCM	TCGA	PATTT	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.2222
p.S415F	DO51269	SKCM	ICGC	VSTPATT	DEG_SCF_FBW7_1	404:410	Mutation rewiring degron network	0.1944
p.S415F	DO51269	SKCM	ICGC	PATTT	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.2222
p.I577L	DO470	BLCA	ICGC	PPSY	ITCH	581:584	Mutation rewiring degron network	0.2222
p.N341S	DO869	BOCA	ICGC	NPPATVVPQ	DEG_SIAH_1	343:351	Mutation rewiring degron network	0.2778
p.H353Y	DO225218	BRCA	ICGC	NPPATVVPQ	DEG_SIAH_1	343:351	Mutation rewiring degron network	0.2778
p.H353Y	DO227939	BRCA	ICGC	NPPATVVPQ	DEG_SIAH_1	343:351	Mutation rewiring degron network	0.2778
p.V171I	DO222427	BTCA	ICGC	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.1944
p.V160L	DO229380	BTCA	ICGC	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation altering degron motif	0.6765
p.R152W	DO230339	COCA	ICGC	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.1111
p.R152W	SIDM01169	Ovarian Carcinoma	GDSC	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.1111
p.R152W	ACH-000885	Ovarian Cancer	CCLE	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.1111
p.R152W	TOV-21G	ovary	COSMIC	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.1111
p.P820H	DO227709	COCA	ICGC	LRPSLFVLS	DEG_APCC_DBOX_1	811:819	Mutation rewiring degron network	0.3056
p.P780S	DO229013	COCA	ICGC	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation altering degron motif	0.6752
p.F572L	DO233081	GACA	ICGC	PPSY	ITCH	581:584	Mutation rewiring degron network	0.0833
p.T175M	DO233867	GACA	ICGC	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.0833
p.S153I	DO228952	LICA	ICGC	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.1389
p.V171F	DO229034	LICA	ICGC	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.1944
p.P164S	DO229177	LMS	ICGC	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation altering degron motif	0.5641
p.A777T	DO228338	MALY	ICGC	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation blocking phosphorylation signal	0.6944
p.D339N	DO222572	MELA	ICGC	NPPATVVPQ	DEG_SIAH_1	343:351	Mutation rewiring degron network	0.2222
p.P794L	DO51958	PRAD	ICGC	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation rewiring degron network	0.1389
p.V416M	DO38551	STAD	ICGC	VSTPATT	DEG_SCF_FBW7_1	404:410	Mutation rewiring degron network	0.1667
p.V416M	DO38551	STAD	ICGC	PATTT	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1944
p.S336F	DO41572	UCEC	ICGC	NPPATVVPQ	DEG_SIAH_1	343:351	Mutation rewiring degron network	0.1389
p.K159N	DO41361	UCEC	ICGC	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.3056
p.R406W	DO41331	UCEC	ICGC	VSTPATT	DEG_SCF_FBW7_1	404:410	Mutation altering degron motif	0.8634
p.P345L	SIDM01955	Colorectal Carcinoma	GDSC	NPPATVVPQ	DEG_SIAH_1	343:351	Mutation altering degron motif	0.6471
p.P345L	ACH-002309	Sarcoma	CCLE	NPPATVVPQ	DEG_SIAH_1	343:351	Mutation altering degron motif	0.6471
p.P345L	SW684	soft tissue	COSMIC	NPPATVVPQ	DEG_SIAH_1	343:351	Mutation altering degron motif	0.6471
p.S397R	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSTPATT	DEG_SCF_FBW7_1	404:410	Mutation rewiring degron network	0.1389
p.S397R	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	PATTT	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.0556
p.P589L	SIDM01175	Other Sarcomas	GDSC	PPSY	ITCH	581:584	Mutation rewiring degron network	0.1944
p.P589L	SW684	soft tissue	COSMIC	PPSY	ITCH	581:584	Mutation rewiring degron network	0.1944
p.R782W	SIDM01638	Non-Cancerous	GDSC	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation altering degron motif	0.7523
p.A825V	SIDM00654	Small Cell Lung Carcinoma	GDSC	LRPSLFVLS	DEG_APCC_DBOX_1	811:819	Mutation rewiring degron network	0.1667
p.A825V	SIDM01525	Acute Myeloid Leukemia	GDSC	LRPSLFVLS	DEG_APCC_DBOX_1	811:819	Mutation rewiring degron network	0.1667
p.Y584C	SIDM00231	Kidney Carcinoma	GDSC	PPSY	ITCH	581:584	Mutation altering degron motif	0.7087
p.Y584C	NCC010	kidney	COSMIC	PPSY	ITCH	581:584	Mutation altering degron motif	0.7087
p.A572V	SIDM00282	Colorectal Carcinoma	GDSC	PPSY	ITCH	581:584	Mutation rewiring degron network	0.0833
p.A572V	CW-2	large intestine	COSMIC	PPSY	ITCH	581:584	Mutation rewiring degron network	0.0833
p.A818T	SIDM00488	Colorectal Carcinoma	GDSC	LRPSLFVLS	DEG_APCC_DBOX_1	811:819	Mutation altering degron motif	0.7139
p.A157S	SIDM01102	Non-Cancerous	GDSC	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.25
p.A157S	ACH-002316	Non-Cancerous	CCLE	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.25
p.A157S	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.25
p.V775M	SIDM01569	Hepatocellular Carcinoma	GDSC	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation rewiring degron network	0.1944
p.S153R	ACH-000124	Lymphoma	CCLE	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.1389
p.E404D	ACH-000783	Breast Cancer	CCLE	VSTPATT	DEG_SCF_FBW7_1	404:410	Mutation altering degron motif	0.6758
p.E404D	CAMA-1	breast	COSMIC	VSTPATT	DEG_SCF_FBW7_1	404:410	Mutation altering degron motif	0.6758
p.V342F	ACH-000901	Lung Cancer	CCLE	NPPATVVPQ	DEG_SIAH_1	343:351	Mutation rewiring degron network	0.3056
p.D397N	ACH-001190	Skin Cancer	CCLE	VSTPATT	DEG_SCF_FBW7_1	404:410	Mutation rewiring degron network	0.1389
p.D397N	ACH-001190	Skin Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.0556
p.D397N	SK-MEL-2	skin	COSMIC	VSTPATT	DEG_SCF_FBW7_1	404:410	Mutation rewiring degron network	0.1389
p.D397N	SK-MEL-2	skin	COSMIC	PATTT	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.0556
p.V399A	ACH-001610	Brain Cancer	CCLE	VSTPATT	DEG_SCF_FBW7_1	404:410	Mutation rewiring degron network	0.1944
p.V399A	ACH-001610	Brain Cancer	CCLE	PATTT	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.1111
p.P792L	ACH-001861	Gallbladder Cancer	CCLE	PARTPPAS	DEG_SCF_FBW7_1	780:787	Mutation rewiring degron network	0.1944
p.Y340C	ACH-002167	Kidney Cancer	CCLE	NPPATVVPQ	DEG_SIAH_1	343:351	Mutation rewiring degron network	0.25
p.Y340C	NCC010	kidney	COSMIC	NPPATVVPQ	DEG_SIAH_1	343:351	Mutation rewiring degron network	0.25
p.H353P	ACH-002176	Lung Cancer	CCLE	NPPATVVPQ	DEG_SIAH_1	343:351	Mutation rewiring degron network	0.2778
p.H353P	NCI-H748	lung	COSMIC	NPPATVVPQ	DEG_SIAH_1	343:351	Mutation rewiring degron network	0.2778
p.T154K	ACH-002664	Colon/Colorectal Cancer	CCLE	LTTPPSS	DEG_SCF_FBW7_1	160:166	Mutation rewiring degron network	0.1667
p.G412R	JHU-011	upper aerodigestive tract	COSMIC	VSTPATT	DEG_SCF_FBW7_1	404:410	Mutation rewiring degron network	0.2778
p.G412R	JHU-011	upper aerodigestive tract	COSMIC	PATTT	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.3056
p.G412R	NCI-H23	lung	COSMIC	VSTPATT	DEG_SCF_FBW7_1	404:410	Mutation rewiring degron network	0.2778
p.G412R	NCI-H23	lung	COSMIC	PATTT	DEG_SPOP_SBC_1	407:411	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYNPO

UniProt ID: Q8N3V7

Entrez ID: 11346

Protein name: Synaptopodin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYNPO in