DegronMD

Uniprot ID: Q8N3V7

Source protein: Synaptopodin

Source gene: SYNPO

Class: DEG_SCF_FBW7_1

Location: 160:166

E3 ligase: FBXW7

DEGRON score: 0.9409

ASA_SCORE: 83.6143

COIL: 0.9109

CONS_SCORE: 0.3581

DSS_SCORE: 0.641

HELIX: 0.0531

FCONS_SCORE: 1.0146

RIG_SCORE: 0.6401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R169C	TCGA-AX-A2HD	UCEC	TCGA	LTTPPSS	DEG_SCF_FBW7_1	0.25
p.T161P	TCGA-EO-A22R	UCEC	TCGA	LTTPPSS	DEG_SCF_FBW7_1	0.5919
p.T161P	DO42713	UCEC	ICGC	LTTPPSS	DEG_SCF_FBW7_1	0.5919
p.A151V	TCGA-G4-6304	COAD	TCGA	LTTPPSS	DEG_SCF_FBW7_1	0.0833
p.A151V	DO10639	COAD	ICGC	LTTPPSS	DEG_SCF_FBW7_1	0.0833
p.V171I	DO222427	BTCA	ICGC	LTTPPSS	DEG_SCF_FBW7_1	0.1944
p.V160L	DO229380	BTCA	ICGC	LTTPPSS	DEG_SCF_FBW7_1	0.6765
p.R152W	DO230339	COCA	ICGC	LTTPPSS	DEG_SCF_FBW7_1	0.1111
p.R152W	SIDM01169	Ovarian Carcinoma	GDSC	LTTPPSS	DEG_SCF_FBW7_1	0.1111
p.R152W	ACH-000885	Ovarian Cancer	CCLE	LTTPPSS	DEG_SCF_FBW7_1	0.1111
p.R152W	TOV-21G	ovary	COSMIC	LTTPPSS	DEG_SCF_FBW7_1	0.1111
p.T175M	DO233867	GACA	ICGC	LTTPPSS	DEG_SCF_FBW7_1	0.0833
p.S153I	DO228952	LICA	ICGC	LTTPPSS	DEG_SCF_FBW7_1	0.1389
p.V171F	DO229034	LICA	ICGC	LTTPPSS	DEG_SCF_FBW7_1	0.1944
p.P164S	DO229177	LMS	ICGC	LTTPPSS	DEG_SCF_FBW7_1	0.5641
p.K159N	DO41361	UCEC	ICGC	LTTPPSS	DEG_SCF_FBW7_1	0.3056
p.A157S	SIDM01102	Non-Cancerous	GDSC	LTTPPSS	DEG_SCF_FBW7_1	0.25
p.A157S	ACH-002316	Non-Cancerous	CCLE	LTTPPSS	DEG_SCF_FBW7_1	0.25
p.A157S	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	LTTPPSS	DEG_SCF_FBW7_1	0.25
p.S153R	ACH-000124	Lymphoma	CCLE	LTTPPSS	DEG_SCF_FBW7_1	0.1389
p.T154K	ACH-002664	Colon/Colorectal Cancer	CCLE	LTTPPSS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3V7	Synaptopodin	DEG_SCF_FBW7_1	160:166	LTTPPSS	FBXW7	0.9409	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons