DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NPPATVVPQ
Uniprot ID:
Q8N3V7
Source protein:
Synaptopodin
Source gene:
SYNPO
Class:
DEG_SIAH_1
Location:
343:351
E3 ligase:
SIAH1,SIAH2,SIAH3
DEGRON score:
0.7185
ASA_SCORE:
89.7111
COIL:
0.953
CONS_SCORE:
0.4284
DSS_SCORE:
0.6943
HELIX:
0.0148
FCONS_SCORE:
0.8794
RIG_SCORE:
0.6764
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S356C
TCGA-DS-A0VN
CESC
TCGA
NPPATVVPQ
DEG_SIAH_1
0.1944
p.N341S
DO869
BOCA
ICGC
NPPATVVPQ
DEG_SIAH_1
0.2778
p.H353Y
DO225218
BRCA
ICGC
NPPATVVPQ
DEG_SIAH_1
0.2778
p.H353Y
DO227939
BRCA
ICGC
NPPATVVPQ
DEG_SIAH_1
0.2778
p.D339N
DO222572
MELA
ICGC
NPPATVVPQ
DEG_SIAH_1
0.2222
p.S336F
DO41572
UCEC
ICGC
NPPATVVPQ
DEG_SIAH_1
0.1389
p.P345L
SIDM01955
Colorectal Carcinoma
GDSC
NPPATVVPQ
DEG_SIAH_1
0.6471
p.P345L
ACH-002309
Sarcoma
CCLE
NPPATVVPQ
DEG_SIAH_1
0.6471
p.P345L
SW684
soft_tissue
COSMIC
NPPATVVPQ
DEG_SIAH_1
0.6471
p.V342F
ACH-000901
Lung Cancer
CCLE
NPPATVVPQ
DEG_SIAH_1
0.3056
p.Y340C
ACH-002167
Kidney Cancer
CCLE
NPPATVVPQ
DEG_SIAH_1
0.25
p.Y340C
NCC010
kidney
COSMIC
NPPATVVPQ
DEG_SIAH_1
0.25
p.H353P
ACH-002176
Lung Cancer
CCLE
NPPATVVPQ
DEG_SIAH_1
0.2778
p.H353P
NCI-H748
lung
COSMIC
NPPATVVPQ
DEG_SIAH_1
0.2778
Drug responses associated with SYNPO mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NPPATVVPQ
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N3V7
Synaptopodin
DEG_SIAH_1
343:351
NPPATVVPQ
SIAH1,SIAH2,SIAH3
0.7185
More...