DegronMD

Uniprot ID: Q8N3V7

Source protein: Synaptopodin

Source gene: SYNPO

Class: DEG_SCF_FBW7_1

Location: 404:410

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 83.3857

COIL: 0.9501

CONS_SCORE: 0.4773

DSS_SCORE: 0.4113

HELIX: 0.0157

FCONS_SCORE: 0.8249

RIG_SCORE: 0.7208

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R395K	TCGA-BH-A2L8	BRCA	TCGA	VSTPATT	DEG_SCF_FBW7_1	0.0833
p.R395K	DO44242	BRCA	ICGC	VSTPATT	DEG_SCF_FBW7_1	0.0833
p.S415F	TCGA-RP-A694	SKCM	TCGA	VSTPATT	DEG_SCF_FBW7_1	0.1944
p.S415F	DO51269	SKCM	ICGC	VSTPATT	DEG_SCF_FBW7_1	0.1944
p.V416M	DO38551	STAD	ICGC	VSTPATT	DEG_SCF_FBW7_1	0.1667
p.R406W	DO41331	UCEC	ICGC	VSTPATT	DEG_SCF_FBW7_1	0.8634
p.S397R	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSTPATT	DEG_SCF_FBW7_1	0.1389
p.E404D	ACH-000783	Breast Cancer	CCLE	VSTPATT	DEG_SCF_FBW7_1	0.6758
p.E404D	CAMA-1	breast	COSMIC	VSTPATT	DEG_SCF_FBW7_1	0.6758
p.D397N	ACH-001190	Skin Cancer	CCLE	VSTPATT	DEG_SCF_FBW7_1	0.1389
p.D397N	SK-MEL-2	skin	COSMIC	VSTPATT	DEG_SCF_FBW7_1	0.1389
p.V399A	ACH-001610	Brain Cancer	CCLE	VSTPATT	DEG_SCF_FBW7_1	0.1944
p.G412R	JHU-011	upper_aerodigestive_tract	COSMIC	VSTPATT	DEG_SCF_FBW7_1	0.2778
p.G412R	NCI-H23	lung	COSMIC	VSTPATT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3V7	Synaptopodin	DEG_SCF_FBW7_1	404:410	VSTPATT	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons