DegronMD

Uniprot ID: Q8N3V7

Source protein: Synaptopodin

Source gene: SYNPO

Class: DEG_SCF_FBW7_1

Location: 780:787

E3 ligase: FBXW7

DEGRON score: 0.9961

ASA_SCORE: 93.75

COIL: 0.9478

CONS_SCORE: 0.8918

DSS_SCORE: 0.4807

HELIX: 0.0345

FCONS_SCORE: 1.2052

RIG_SCORE: 0.6148

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P770T	TCGA-A6-6781	COAD	TCGA	PARTPPAS	DEG_SCF_FBW7_1	0.0556
p.P770T	DO8447	COAD	ICGC	PARTPPAS	DEG_SCF_FBW7_1	0.0556
p.R778Q	TCGA-BS-A0UV	UCEC	TCGA	PARTPPAS	DEG_SCF_FBW7_1	0.2778
p.R778Q	DO42793	UCEC	ICGC	PARTPPAS	DEG_SCF_FBW7_1	0.2778
p.A781S	TCGA-E9-A295	BRCA	TCGA	PARTPPAS	DEG_SCF_FBW7_1	0.6477
p.A781S	DO3703	BRCA	ICGC	PARTPPAS	DEG_SCF_FBW7_1	0.6477
p.A781S	DO232761	PBCA	ICGC	PARTPPAS	DEG_SCF_FBW7_1	0.6477
p.T783P	TCGA-EA-A3HT	CESC	TCGA	PARTPPAS	DEG_SCF_FBW7_1	0.8142
p.R782Q	TCGA-HT-8564	LGG	TCGA	PARTPPAS	DEG_SCF_FBW7_1	0.6218
p.R782Q	DO44623	LGG	ICGC	PARTPPAS	DEG_SCF_FBW7_1	0.6218
p.P780S	DO229013	COCA	ICGC	PARTPPAS	DEG_SCF_FBW7_1	0.6752
p.A777T	DO228338	MALY	ICGC	PARTPPAS	DEG_SCF_FBW7_1	0.6944
p.P794L	DO51958	PRAD	ICGC	PARTPPAS	DEG_SCF_FBW7_1	0.1389
p.R782W	SIDM01638	Non-Cancerous	GDSC	PARTPPAS	DEG_SCF_FBW7_1	0.7523
p.V775M	SIDM01569	Hepatocellular Carcinoma	GDSC	PARTPPAS	DEG_SCF_FBW7_1	0.1944
p.P792L	ACH-001861	Gallbladder Cancer	CCLE	PARTPPAS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons