DegronMD

Uniprot ID: Q9HCH3

Source protein: Copine-5

Source gene: CPNE5

Class: DEG_SCF_FBW7_1

Location: 580:587

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 84.15

COIL: 0.9611

CONS_SCORE: 0.2769

DSS_SCORE: 0.8988

HELIX: 0.0161

FCONS_SCORE: 1.0741

RIG_SCORE: 0.5047

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T591M	TCGA-CD-8536	STAD	TCGA	PARTPPAS	DEG_SCF_FBW7_1	0.2222
p.T591M	DO47827	STAD	ICGC	PARTPPAS	DEG_SCF_FBW7_1	0.2222
p.P584R	TCGA-E2-A14W	BRCA	TCGA	PARTPPAS	DEG_SCF_FBW7_1	0.7512
p.P584R	DO4281	BRCA	ICGC	PARTPPAS	DEG_SCF_FBW7_1	0.7512
p.A581V	TCGA-IB-A7M4	PAAD	TCGA	PARTPPAS	DEG_SCF_FBW7_1	0.5825
p.A581V	DO50261	PAAD	ICGC	PARTPPAS	DEG_SCF_FBW7_1	0.5825
p.R582H	DO230347	COCA	ICGC	PARTPPAS	DEG_SCF_FBW7_1	0.7133
p.R582H	SIDM00216	Colorectal Carcinoma	GDSC	PARTPPAS	DEG_SCF_FBW7_1	0.7133
p.R582H	SIDM00410	Other Blood Cancers	GDSC	PARTPPAS	DEG_SCF_FBW7_1	0.7133
p.R582H	SIDM00469	Pancreatic Carcinoma	GDSC	PARTPPAS	DEG_SCF_FBW7_1	0.7133
p.R582H	SIDM00986	Head and Neck Carcinoma	GDSC	PARTPPAS	DEG_SCF_FBW7_1	0.7133
p.S575L	DO233867	GACA	ICGC	PARTPPAS	DEG_SCF_FBW7_1	0.1944
p.S579Y	DO228948	LICA	ICGC	PARTPPAS	DEG_SCF_FBW7_1	0.3056
p.P572Q	DO228974	LICA	ICGC	PARTPPAS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons