DegronMD

Uniprot ID: Q8N3V7

Source protein: Synaptopodin

Source gene: SYNPO

Class: DEG_APCC_DBOX_1

Location: 811:819

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9923

ASA_SCORE: 74.8778

COIL: 0.6687

CONS_SCORE: 0.7664

DSS_SCORE: 0.4446

HELIX: 0.2863

FCONS_SCORE: 1.0296

RIG_SCORE: 0.7672

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P801S	TCGA-A5-A0GH	UCEC	TCGA	LRPSLFVLS	DEG_APCC_DBOX_1	0.0556
p.P801S	DO43634	UCEC	ICGC	LRPSLFVLS	DEG_APCC_DBOX_1	0.0556
p.R812C	TCGA-BR-4257	STAD	TCGA	LRPSLFVLS	DEG_APCC_DBOX_1	0.8301
p.R812C	DO222817	BTCA	ICGC	LRPSLFVLS	DEG_APCC_DBOX_1	0.8301
p.R812C	DO38683	STAD	ICGC	LRPSLFVLS	DEG_APCC_DBOX_1	0.8301
p.P807S	TCGA-EO-A22R	UCEC	TCGA	LRPSLFVLS	DEG_APCC_DBOX_1	0.2222
p.P807S	DO42713	UCEC	ICGC	LRPSLFVLS	DEG_APCC_DBOX_1	0.2222
p.I821L	TCGA-GV-A3QI	BLCA	TCGA	LRPSLFVLS	DEG_APCC_DBOX_1	0.2778
p.P820H	DO227709	COCA	ICGC	LRPSLFVLS	DEG_APCC_DBOX_1	0.3056
p.A825V	SIDM00654	Small Cell Lung Carcinoma	GDSC	LRPSLFVLS	DEG_APCC_DBOX_1	0.1667
p.A825V	SIDM01525	Acute Myeloid Leukemia	GDSC	LRPSLFVLS	DEG_APCC_DBOX_1	0.1667
p.A818T	SIDM00488	Colorectal Carcinoma	GDSC	LRPSLFVLS	DEG_APCC_DBOX_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3V7	Synaptopodin	DEG_APCC_DBOX_1	811:819	LRPSLFVLS	APC,CDC20,FZR1	0.9923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons